1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene

Base Information

• Chemical Name: 1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene
• CAS No.: 71721-13-6
• Molecular Formula: C₁₄H₁₃ClO₂S
• Molecular Weight: 280.775
• Mol file: 71721-13-6.mol

Synonyms:

Chemical Property of 1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene

There total 8 articles about 1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-(phenylsulfonyl)-1-(trimethylsilyl)ethene (69627-08-3) + chlorobenzene (108-90-7) → 1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene (71721-13-6)

Guidance literature:

With tetrabutyl ammonium fluoride; water; sec.-butyllithium; regioselectivity (ortho to chlorine), also with OMe-, OSiMe₂-t-bu- and Cl-substituted chlorobenzenes;

DOI:10.1021/jo00298a045

Reference yield:

2-chlorophenylacetic acid ethyl ester (40061-54-9) → 1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene (71721-13-6)

Guidance literature:

Multi-step reaction with 4 steps

1: LiAlH₄ / diethyl ether

2: SOCl₂, pyridine

3: NaOEt / ethanol / Heating

4: aq. H₂O₂

With pyridine; lithium aluminium tetrahydride; thionyl chloride; dihydrogen peroxide; sodium ethanolate; In diethyl ether; ethanol;

DOI:10.1021/jo01058a019

Reference yield:

2-(2-chlorophenyl)-1-ethanol (19819-95-5) → 1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene (71721-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂, pyridine

2: NaOEt / ethanol / Heating

3: aq. H₂O₂

With pyridine; thionyl chloride; dihydrogen peroxide; sodium ethanolate; In ethanol;

DOI:10.1021/jo01058a019

upstream raw materials:

1-(2-Benzenesulfinyl-ethyl)-2-chloro-benzene

1-(phenylsulfonyl)-1-(trimethylsilyl)ethene

chlorobenzene

1-Phenylmercapto-2-<2-chlor-phenyl>-ethan

Downstream raw materials:

C₁₆H₁₄Cl₂

1-(phenylsulfonyl)benzocyclobutene

7-Benzenesulfonyl-7-hex-5-enyl-bicyclo[4.2.0]octa-1,3,5-triene

7-Benzenesulfonyl-7-pent-4-enyl-bicyclo[4.2.0]octa-1,3,5-triene

Refernces