methyl 11,21-dihydroxy-3,20-dioxopregna-1,4-diene-16-carboxylate

Base Information

Chemical Name:methyl 11,21-dihydroxy-3,20-dioxopregna-1,4-diene-16-carboxylate
CAS No.:111802-43-8
Molecular Formula:C23H30 O6
Molecular Weight:402.4807
Hs Code.:

Synonyms:DP16CM

Suppliers and Price of methyl 11,21-dihydroxy-3,20-dioxopregna-1,4-diene-16-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of methyl 11,21-dihydroxy-3,20-dioxopregna-1,4-diene-16-carboxylate

Chemical Property:

Vapor Pressure:1.41E-15mmHg at 25°C
Boiling Point:574.2°C at 760 mmHg
Flash Point:196.1°C
Density:1.28g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methyl 11,21-dihydroxy-3,20-dioxopregna-1,4-diene-16-carboxylate

There total 7 articles about methyl 11,21-dihydroxy-3,20-dioxopregna-1,4-diene-16-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 67-56-1
methanol

: 119465-19-9
11β,21-dihydroxy-3,20-dioxo-1,4-pregnadiene-16α-carboxylic acid

: 111802-43-8
methyl 11β,21-dihydroxy-3,20-dioxo-1,4-pregnadiene-16α-carboxylate

Guidance literature:: With sulfuric acid; for 2h; Heating;

Reference yield:

: 50-24-8,8056-11-9
prednisolon

: 111802-43-8
methyl 11β,21-dihydroxy-3,20-dioxo-1,4-pregnadiene-16α-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / pyridinium p-toluenesulfonate / benzene / 1 h / Heating

2: 84 percent / 2percent acetic acid / methanol / 2 h / Ambient temperature

3: 88 percent / pyridine / 2 h / Ambient temperature

4: 60 percent / KOAc / dimethylformamide / 6 h / 90 - 100 °C

5: 72 percent / 18-crown-6, NH₄Cl / dimethylsulfoxide; H₂O / 1.5 h / 85 - 90 °C

6: 90 percent / HCl / H₂O / 2 h / Heating

7: 40 percent / H₂SO₄ / 2 h / Heating

With pyridine; hydrogenchloride; 18-crown-6 ether; sulfuric acid; potassium acetate; pyridinium p-toluenesulfonate; ammonium chloride; acetic acid; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;

Reference yield:

: 3044-42-6
21-acetoxy-11β-hydroxyl-1,4,16-pregnatriene-3,20-dione

: 111802-43-8
methyl 11β,21-dihydroxy-3,20-dioxo-1,4-pregnadiene-16α-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / 18-crown-6, NH₄Cl / dimethylsulfoxide; H₂O / 1.5 h / 85 - 90 °C

2: 90 percent / HCl / H₂O / 2 h / Heating

3: 40 percent / H₂SO₄ / 2 h / Heating

With hydrogenchloride; 18-crown-6 ether; sulfuric acid; ammonium chloride; In water; dimethyl sulfoxide;