10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate

Base Information

• Chemical Name: 10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate
• CAS No.: 123948-98-1
• Molecular Formula: CH₃O₃S*C₂₄H₂₆N₃O₅
• Molecular Weight: 531.587
• Mol file: 123948-98-1.mol

Synonyms:

Chemical Property of 10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate

There total 1 articles about 10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl methanesulfonate (66-27-3) + topotecan (123948-87-8) → C21H18N2O6 (175613-38-4) + CH4O3S*C23H23N3O5 + CH3O3S(1-)*C25H28N3O5(1+) + 10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate (123948-98-1)

Guidance literature:

Methyl methanesulfonate; With potassium carbonate; In dichloromethane; for 0.5h;

topotecan; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/mrc.2625

upstream raw materials:

Methyl methanesulfonate

topotecan

Refernces