3-(difluoromethyl)-2-fluoroaniline

Base Information

• Chemical Name: 3-(difluoromethyl)-2-fluoroaniline
• CAS No.: 1784796-42-4
• Molecular Formula: C₇H₆F₃N
• Molecular Weight: 161.127
• Mol file: 1784796-42-4.mol

Synonyms:

Chemical Property of 3-(difluoromethyl)-2-fluoroaniline

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(difluoromethyl)-2-fluoroaniline

There total 3 articles about 3-(difluoromethyl)-2-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(difluoromethyl)-2-fluoro-3-nitro-benzene → 3-(difluoromethyl)-2-fluoroaniline (1784796-42-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 27 ℃; for 17h; under 775.743 Torr;

Reference yield:

2-fluoro-3-nitrobenzaldehyde (96516-29-9) → 3-(difluoromethyl)-2-fluoroaniline (1784796-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 96 h / 10 - 20 °C / 1551.49 Torr / Inert atmosphere

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;

Reference yield:

2-chloro-3-nitrobenzaldehyde (58755-57-0) → 3-(difluoromethyl)-2-fluoroaniline (1784796-42-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium fluoride / N,N-dimethyl-formamide / 5 h / 150 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 0 °C

3: palladium on activated charcoal; hydrogen / methanol / 17 h / 28 °C / 775.74 Torr

With potassium fluoride; diethylamino-sulfur trifluoride; palladium on activated charcoal; hydrogen; In methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-fluoro-3-nitrobenzaldehyde

2-chloro-3-nitrobenzaldehyde