((1R,2R,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2R,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-1,2,3,4-tetrahydro-dibenzo[c,h]acridin-4-yl ester

Base Information

• Chemical Name: ((1R,2R,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2R,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-1,2,3,4-tetrahydro-dibenzo[c,h]acridin-4-yl ester
• CAS No.: 93756-14-0
• Molecular Formula: C₄₅H₅₇NO₆
• Molecular Weight: 707.951
• Mol file: 93756-14-0.mol

Synonyms:

Chemical Property of ((1R,2R,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2R,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-1,2,3,4-tetrahydro-dibenzo[c,h]acridin-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1R,2R,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2R,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-1,2,3,4-tetrahydro-dibenzo[c,h]acridin-4-yl ester

There total 17 articles about ((1R,2R,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2R,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-1,2,3,4-tetrahydro-dibenzo[c,h]acridin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((1R,2R,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2R,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-3,4-dihydro-dibenzo[c,h]acridin-4-yl ester (93716-10-0,93780-90-6) → ((1R,2R,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2R,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-1,2,3,4-tetrahydro-dibenzo[c,h]acridin-4-yl ester (93756-14-0,93859-89-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; for 0.166667h; under 760 Torr; Ambient temperature;

DOI:10.1021/jo00201a019

Reference yield:

α-naphthol (90-15-3) → ((1R,2R,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2R,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-1,2,3,4-tetrahydro-dibenzo[c,h]acridin-4-yl ester (93756-14-0,93859-89-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 12.9 percent / 0.25 h / 250 °C

3: 88 percent / 25percent aq. NaOH / tetrahydrofuran; methanol / 5 h / Ambient temperature

4: 92 percent / pyridine / 24 h / Ambient temperature

5: 96 percent / NBS, AIBN / CCl₄ / 0.25 h / 60 - 62 °C

6: 66 percent / Li₂CO₃, LiF / hexamethylphosphoric acid triamide / 3 h / 85 - 90 °C

7: 93 percent / NH₃ / methanol; tetrahydrofuran / 4 h / Ambient temperature

8: pyridine / 25 h / 0 - 5 °C

9: H₂ / 10percent Pd/C / 0.17 h / 760 Torr / Ambient temperature

With pyridine; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; hydrogen; lithium carbonate; lithium fluoride; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1021/jo00201a019

Reference yield:

1-amino-5,6,7,8-tetrahydronaphthalene (2217-41-6) → ((1R,2R,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2R,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-1,2,3,4-tetrahydro-dibenzo[c,h]acridin-4-yl ester (93756-14-0,93859-89-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 12.9 percent / 0.25 h / 250 °C

3: 88 percent / 25percent aq. NaOH / tetrahydrofuran; methanol / 5 h / Ambient temperature

4: 92 percent / pyridine / 24 h / Ambient temperature

5: 96 percent / NBS, AIBN / CCl₄ / 0.25 h / 60 - 62 °C

6: 66 percent / Li₂CO₃, LiF / hexamethylphosphoric acid triamide / 3 h / 85 - 90 °C

7: 93 percent / NH₃ / methanol; tetrahydrofuran / 4 h / Ambient temperature

8: pyridine / 25 h / 0 - 5 °C

9: H₂ / 10percent Pd/C / 0.17 h / 760 Torr / Ambient temperature

With pyridine; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; hydrogen; lithium carbonate; lithium fluoride; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1021/jo00201a019

upstream raw materials:

trans-3,4-dihydroxy-1,2,3,4-tetrahydrodibenzacridine

(-)-menthoxyacetyl chloride

α-naphthol

1-amino-5,6,7,8-tetrahydronaphthalene