N-benzoyl-α-benzylthioglycine methyl ester

Base Information

• Chemical Name: N-benzoyl-α-benzylthioglycine methyl ester
• CAS No.: 56538-62-6
• Molecular Formula: C₁₇H₁₇NO₃S
• Molecular Weight: 315.393
• Mol file: 56538-62-6.mol

Synonyms:

Chemical Property of N-benzoyl-α-benzylthioglycine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzoyl-α-benzylthioglycine methyl ester

There total 8 articles about N-benzoyl-α-benzylthioglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

dibenzyl disulphide (150-60-7) + N-benzoyl-2-bromoglycine methyl ester (101649-82-5) → methyl hippurate (1205-08-9) + N-benzoyl-α-benzylthioglycine methyl ester (56538-62-6)

Guidance literature:

With tri-n-butyl-tin hydride; In benzene; for 16h; Heating;

Reference yield: 24.0%

dibenzyl disulphide (150-60-7) + N-benzoyl-α-benzoyloxyglycine methyl ester (110339-43-0) → N-benzoyl-α-benzylthioglycine methyl ester (56538-62-6) + (+/-)-dimethyl-2,3-dibenzamidobutanedioate (258505-90-7)

Guidance literature:

With bis(tri-n-butyltin); In benzene; Heating; Irradiation;

DOI:10.1016/S0040-4039(00)61151-6

Reference yield:

N-benzoyl-2-bromoglycine methyl ester (101649-82-5) → N-benzoyl-α-benzylthioglycine methyl ester (56538-62-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / Et₃N / 0.25 h / Ambient temperature

2: 4 percent / t-Bu₂S₂, Bu₃Sn-SnBu₃ / benzene / 14 h / Irradiation

3: 2 percent / t-Bu₂O₂ / benzene / 15 h / Irradiation

4: 55 percent Spectr_. / Bu₃Sn-SnBu₃ / benzene / 6 h / Irradiation

With di-tert-butyl disulfide; di-tert-butyl peroxide; bis(tri-n-butyltin); triethylamine; In benzene;

upstream raw materials:

dibenzyl disulphide

methyl N-benzoyl-2-methoxyglycinate

N-benzoyl-2-bromoglycine methyl ester

N-benzoyl-α-benzoyloxyglycine methyl ester

Downstream raw materials:

methyl N-benzoyl-2-methoxyglycinate

Methyl-α-butylthiohippurat

Methyl-α-isopropylsulfoxyhippurat

Methyl-α-isopropylthiohippurat