Multi-step reaction with 8 steps
1: HONB, DCC / tetrahydrofuran / 15 h
2: H2 / Pd-black / methanol / Ambient temperature
3: dimethylformamide / 15 h
4: H2 / Pd-black / methanol / Ambient temperature
5: HONB, DCC / dimethylformamide / 15 h
6: H2, TsOH*H2O / Pd-black / methanol / Ambient temperature
7: Et3N / dimethylformamide / 15 h
8: H2 / Pd-black / methanol / Ambient temperature
With
hydrogen; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide);
palladium;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;