L-Alanine, N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: L-Alanine, N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester
• CAS No.: 50300-96-4
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.336
• Mol file: 50300-96-4.mol

Synonyms:1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester;trans methyl 1,2,3,4-tetrahydro-1-phenyl-9H-pyrido[3,4-b]indole-3-carboxylate;methyl-1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate;methyl 1-phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate;1-Phenyl-2,3,4,9-tetrahydro-1H-β-carbolin-3-carbonsaeure-methylester;methyl 1-phenyl-1,2,3,4-tetrahydro-8-carboline-3-carboxylate;

Chemical Property of L-Alanine, N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 397.3±35.0 °C(Predicted)
• PSA: 64.63000
• Density: 1.099±0.06 g/cm3(Predicted)
• LogP: 3.03390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Alanine, N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester

There total 9 articles about L-Alanine, N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-Cbz-Ala (1142-20-7) + 2-tert-Butyl-1,3-bis-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-isourea (159390-24-6) → (S)-2-(benzyloxycarbonylamino)propionic acid tert-butyl ester (50300-96-4)

Guidance literature:

In toluene; at 80 - 85 ℃; for 20h;

DOI:10.1021/jo00103a054

Reference yield: 92.0%

t-butyl bromide (507-19-7) + N-Cbz-Ala (1142-20-7) → (S)-2-(benzyloxycarbonylamino)propionic acid tert-butyl ester (50300-96-4)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In N,N-dimethyl acetamide; at 55 ℃; for 24h;

DOI:10.1016/S0040-4039(00)60139-9

Reference yield: 87.0%

N-Cbz-Ala (1142-20-7) + tert-butyl alcohol (75-65-0) → (S)-2-(benzyloxycarbonylamino)propionic acid tert-butyl ester (50300-96-4)

Guidance literature:

With sulfuric acid; magnesium sulfate; In dichloromethane; at 25 ℃; for 18h;

DOI:10.1016/S0040-4039(97)01792-9

upstream raw materials:

t-butyl bromide

N-Cbz-Ala

di-tert-butyl dicarbonate

tert-butyl alcohol

Downstream raw materials:

Ala-OtBu

tert-butyl L-alaninate hydrochloride

N-Cbz-Ala

tert-butyl nitrate