Technology Process of 1H-Naphtho[2,1-b][1,4]thiazin-2(3H)-one,
3-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-
There total 4 articles about 1H-Naphtho[2,1-b][1,4]thiazin-2(3H)-one,
3-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: KOH / 2-methoxy-ethanol; H2O / Heating
2: 50.8 percent / dimethylformamide / Ambient temperature
3: 71.4 percent / ethyl acetate / 110 °C
With
potassium hydroxide;
In
2-methoxy-ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2888
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2.) 2 N NaOH / 1.) acetone, 50 deg C 2.) reflux
2: 1.) bromine, AcOH 2.) 25percent NH4OH / 1.) room temp. 2.) room temp.
3: KOH / 2-methoxy-ethanol; H2O / Heating
4: 50.8 percent / dimethylformamide / Ambient temperature
5: 71.4 percent / ethyl acetate / 110 °C
With
potassium hydroxide; ammonium hydroxide; sodium hydroxide; bromine; acetic acid;
In
2-methoxy-ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2888
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) bromine, AcOH 2.) 25percent NH4OH / 1.) room temp. 2.) room temp.
2: KOH / 2-methoxy-ethanol; H2O / Heating
3: 50.8 percent / dimethylformamide / Ambient temperature
4: 71.4 percent / ethyl acetate / 110 °C
With
potassium hydroxide; ammonium hydroxide; bromine; acetic acid;
In
2-methoxy-ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2888