Naphtho[1,2-d]thiazol-2-amine

Base Information

Chemical Name:Naphtho[1,2-d]thiazol-2-amine
CAS No.:40172-65-4
Molecular Formula:C11H8N2S
Molecular Weight:200.264
Hs Code.:2934999090
European Community (EC) Number:254-822-1
NSC Number:6278
UNII:SW12CAS9T7
DSSTox Substance ID:DTXSID2068216
Nikkaji Number:J308.261J
Wikidata:Q27088806
Pharos Ligand ID:8186WD19JSKC
ChEMBL ID:CHEMBL1709719
Mol file:40172-65-4.mol

Synonyms:naphtho(1,2-d)thiazol-2-ylamine;SKA-31

Suppliers and Price of Naphtho[1,2-d]thiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SKA 31
10mg
$ 366.00

Tocris
SKA31 ≥99%(HPLC)
50
$ 515.00

Tocris
SKA31 ≥99%(HPLC)
10
$ 123.00

Sigma-Aldrich
SKA-31 ≥98% (HPLC)
25mg
$ 582.00

Sigma-Aldrich
SKA-31 ≥98% (HPLC)
5mg
$ 107.00

Matrix Scientific
Naphtho[1,2-d]thiazol-2-ylamine 95%+
2.500g
$ 476.00

Matrix Scientific
Naphtho[1,2-d]thiazol-2-ylamine 95%+
5g
$ 720.00

Matrix Scientific
Naphtho[1,2-d]thiazol-2-ylamine 95%+
1g
$ 218.00

ChemScene
SKA-31 99.38%
100mg
$ 65.00

ChemScene
SKA-31 99.38%
1g
$ 275.00

Total 22 raw suppliers

Chemical Property of Naphtho[1,2-d]thiazol-2-amine

Chemical Property:

Vapor Pressure:3.63E-07mmHg at 25°C
Melting Point:184-188oC
Boiling Point:417.1°C at 760 mmHg
PKA:3.50±0.30(Predicted)
Flash Point:206.1°C
PSA：67.15000
Density:1.403g/cm³
LogP:3.61290
Storage Temp.:Store at +4°C
Solubility.:DMSO: ≥30mg/mL
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:200.04081944
Heavy Atom Count:14
Complexity:221

Purity/Quality:

99%, ^*data from raw suppliers

SKA 31 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 20/21/22-36/37/38-36-22
Safety Statements: 22-36/37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=CC3=C2N=C(S3)N
Description SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3

Technology Process of Naphtho[1,2-d]thiazol-2-amine

There total 9 articles about Naphtho[1,2-d]thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 17356-08-0
thiourea

: 529-34-0
3,4-dihydronaphthalene-1(2H)-one

: 40172-65-4
SKA-31

Guidance literature:: With iodine; oxygen; toluene-4-sulfonic acid; In dimethyl sulfoxide; at 75 ℃; for 24h; under 760.051 Torr;
DOI:10.1021/ol400773k