1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl-

Base Information

Chemical Name:1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl-
CAS No.:139335-24-3
Molecular Formula:C11H8N2O3S
Molecular Weight:248.262
Hs Code.:

Synonyms:

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Chemical Property of 1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl-

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Technology Process of 1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl-

There total 10 articles about 1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 139335-23-2
ethyl 2-benzoyl-1,3,4-thiadiazol-5-ylacetate

: 139335-24-3
2-benzoyl-1,3,4-thiadiazol-5-ylacetic acid

Guidance literature:: With potassium carbonate; In ethanol; water; at 60 ℃; for 2h;
DOI:10.1248/cpb.39.2837

Reference yield:

: 26155-37-3
phenylacetaldehyde methylthio(thiocarbonyl)hydrazone

: 139335-24-3
2-benzoyl-1,3,4-thiadiazol-5-ylacetic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 98 percent / CHCl₃ / 0.5 h / Heating

2: 92 percent / m-CPBA / CHCl₃ / 0.5 h / Ambient temperature

3: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 min

4: 93 percent / m-CPBA / CHCl₃ / 0.5 h / Ambient temperature

5: 82 percent / 4-dimethylaminopyridine (DMAP) / ethanol / 0.5 h / Heating

6: 88 percent / N-bromosuccinimide (NBS) / benzoyl peroxide / CCl₄ / 0.02 h / Heating

7: 92 percent / CrO₃ / acetic acid / 0.5 h / 60 °C

8: 94 percent / Zn, AcOH / 0.5 h / Ambient temperature

9: 69 percent / pyridinium dichromate (PDC) / CH₂Cl₂ / 4 h / Ambient temperature

10: 85 percent / K₂CO₃ / ethanol; H₂O / 2 h / 60 °C

With chromium(VI) oxide; dmap; N-Bromosuccinimide; dipyridinium dichromate; n-butyllithium; potassium carbonate; acetic acid; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; zinc; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; chloroform; water; acetic acid;
DOI:10.1248/cpb.39.2837

Reference yield:

: 139335-19-6
ethyl 2-benzyl-1,3,4-thiadiazol-5-ylacetate

: 139335-24-3
2-benzoyl-1,3,4-thiadiazol-5-ylacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / N-bromosuccinimide (NBS) / benzoyl peroxide / CCl₄ / 0.02 h / Heating

2: 92 percent / CrO₃ / acetic acid / 0.5 h / 60 °C

3: 94 percent / Zn, AcOH / 0.5 h / Ambient temperature

4: 69 percent / pyridinium dichromate (PDC) / CH₂Cl₂ / 4 h / Ambient temperature

5: 85 percent / K₂CO₃ / ethanol; H₂O / 2 h / 60 °C

With chromium(VI) oxide; N-Bromosuccinimide; dipyridinium dichromate; potassium carbonate; acetic acid; zinc; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; water; acetic acid;
DOI:10.1248/cpb.39.2837