1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl-, ethyl ester

Base Information

Chemical Name:1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl-, ethyl ester
CAS No.:139335-23-2
Molecular Formula:C13H12N2O3S
Molecular Weight:276.316
Hs Code.:

Synonyms:

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Chemical Property of 1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl-, ethyl ester

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Technology Process of 1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl-, ethyl ester

There total 9 articles about 1,3,4-Thiadiazole-2-acetic acid, 5-benzoyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: ethyl 2-(α-hydroxybenzyl)-1,3,4-thiadiazol-5-ylacetate

: 139335-23-2
ethyl 2-benzoyl-1,3,4-thiadiazol-5-ylacetate

Guidance literature:: With dipyridinium dichromate; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1248/cpb.39.2837

Reference yield:

: 26155-37-3
phenylacetaldehyde methylthio(thiocarbonyl)hydrazone

: 139335-23-2
ethyl 2-benzoyl-1,3,4-thiadiazol-5-ylacetate

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / CHCl₃ / 0.5 h / Heating

2: 92 percent / m-CPBA / CHCl₃ / 0.5 h / Ambient temperature

3: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 min

4: 93 percent / m-CPBA / CHCl₃ / 0.5 h / Ambient temperature

5: 82 percent / 4-dimethylaminopyridine (DMAP) / ethanol / 0.5 h / Heating

6: 88 percent / N-bromosuccinimide (NBS) / benzoyl peroxide / CCl₄ / 0.02 h / Heating

7: 92 percent / CrO₃ / acetic acid / 0.5 h / 60 °C

8: 94 percent / Zn, AcOH / 0.5 h / Ambient temperature

9: 69 percent / pyridinium dichromate (PDC) / CH₂Cl₂ / 4 h / Ambient temperature

With chromium(VI) oxide; dmap; N-Bromosuccinimide; dipyridinium dichromate; n-butyllithium; acetic acid; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; zinc; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; chloroform; acetic acid;
DOI:10.1248/cpb.39.2837

Reference yield:

: 139335-19-6
ethyl 2-benzyl-1,3,4-thiadiazol-5-ylacetate

: 139335-23-2
ethyl 2-benzoyl-1,3,4-thiadiazol-5-ylacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / N-bromosuccinimide (NBS) / benzoyl peroxide / CCl₄ / 0.02 h / Heating

2: 92 percent / CrO₃ / acetic acid / 0.5 h / 60 °C

3: 94 percent / Zn, AcOH / 0.5 h / Ambient temperature

4: 69 percent / pyridinium dichromate (PDC) / CH₂Cl₂ / 4 h / Ambient temperature

With chromium(VI) oxide; N-Bromosuccinimide; dipyridinium dichromate; acetic acid; zinc; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; acetic acid;
DOI:10.1248/cpb.39.2837