Technology Process of ethyl 2-benzyl-1,3,4-thiadiazol-5-yldibromoacetate
There total 6 articles about ethyl 2-benzyl-1,3,4-thiadiazol-5-yldibromoacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide;
dibenzoyl peroxide;
In
tetrachloromethane;
for 0.0166667h;
Heating;
DOI:10.1248/cpb.39.2837
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / CHCl3 / 0.5 h / Heating
2: 92 percent / m-CPBA / CHCl3 / 0.5 h / Ambient temperature
3: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 min
4: 93 percent / m-CPBA / CHCl3 / 0.5 h / Ambient temperature
5: 82 percent / 4-dimethylaminopyridine (DMAP) / ethanol / 0.5 h / Heating
6: 88 percent / N-bromosuccinimide (NBS) / benzoyl peroxide / CCl4 / 0.02 h / Heating
With
dmap; N-Bromosuccinimide; n-butyllithium; diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
dibenzoyl peroxide;
In
tetrachloromethane; ethanol; chloroform;
DOI:10.1248/cpb.39.2837
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / m-CPBA / CHCl3 / 0.5 h / Ambient temperature
2: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 min
3: 93 percent / m-CPBA / CHCl3 / 0.5 h / Ambient temperature
4: 82 percent / 4-dimethylaminopyridine (DMAP) / ethanol / 0.5 h / Heating
5: 88 percent / N-bromosuccinimide (NBS) / benzoyl peroxide / CCl4 / 0.02 h / Heating
With
dmap; N-Bromosuccinimide; n-butyllithium; diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
dibenzoyl peroxide;
In
tetrachloromethane; ethanol; chloroform;
DOI:10.1248/cpb.39.2837
