Technology Process of 1,3-dimethyl-4-pyridone-2-carboxanilide
There total 7 articles about 1,3-dimethyl-4-pyridone-2-carboxanilide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) KOH; 2.) H2O2 / 2.) AcOH
2: HNO3/H2SO4
3: PCl3 / CHCl3 / 1.5 h / Heating
4: triethylamine / CH2Cl2
5: 93 percent / methanol / 4 h
6: 76 percent / 1.) N,N,N',N'-tetramethylethylenediamine, n-BuLi; / 1.) THF, -78 deg C, 0.5 h, -23 deg C, 2 h; 2.) THF, -78 deg C to rt. 2 h.
7: 96 percent / conc. hydrochloric acid / 48 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; dihydrogen peroxide; nitric acid; triethylamine; phosphorus trichloride;
In
methanol; dichloromethane; chloroform;
DOI:10.1016/S0040-4020(01)89209-7
- Guidance literature:
-
Multi-step reaction with 6 steps
1: HNO3/H2SO4
2: PCl3 / CHCl3 / 1.5 h / Heating
3: triethylamine / CH2Cl2
4: 93 percent / methanol / 4 h
5: 76 percent / 1.) N,N,N',N'-tetramethylethylenediamine, n-BuLi; / 1.) THF, -78 deg C, 0.5 h, -23 deg C, 2 h; 2.) THF, -78 deg C to rt. 2 h.
6: 96 percent / conc. hydrochloric acid / 48 h / Ambient temperature
With
hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; nitric acid; triethylamine; phosphorus trichloride;
In
methanol; dichloromethane; chloroform;
DOI:10.1016/S0040-4020(01)89209-7
