3-methoxy-7-methyl-9-phenylthio-4bα,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one

Base Information

• Chemical Name: 3-methoxy-7-methyl-9-phenylthio-4bα,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one
• CAS No.: 83637-59-6
• Molecular Formula: C₂₄H₂₆O₂S
• Molecular Weight: 378.535
• Mol file: 83637-59-6.mol

Synonyms:

Chemical Property of 3-methoxy-7-methyl-9-phenylthio-4bα,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-7-methyl-9-phenylthio-4bα,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one

There total 20 articles about 3-methoxy-7-methyl-9-phenylthio-4bα,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxybenzocyclobuten-1-yl toluene-p-sulphonate (30267-36-8) → 3-methoxy-7-methyl-9-phenylthio-4bα,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one (83637-59-6,98115-44-7,98169-15-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 95 percent / NaH / dimethylformamide / 1 h / 0 °C

2: 90 percent / MCPBA / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 85 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 °C

4: 90 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

5: 90 percent / zinc, AcOH / 1 h / Ambient temperature

6: 88 percent / H₂ / 10percent Pd-C / methanol / 12 h

7: 89 percent / NaH / benzene / 3 h / Ambient temperature

8: pyridine / 0.5 h / Ambient temperature

9: 84 percent / 2 h / Ambient temperature

10: various solvent(s) / 10 h / Heating

With pyridine; hydrogen; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; zinc; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; benzene;

Reference yield:

5-methoxybenzocyclobuten-1-yl toluene-p-sulphonate (30267-36-8) → 3-methoxy-7-methyl-9-phenylthio-4bβ,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one (83637-59-6,98115-44-7,98169-15-4)

Guidance literature:

Multi-step reaction with 10 steps

1: 95 percent / NaH / dimethylformamide / 1 h / 0 °C

2: 90 percent / MCPBA / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 85 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / -78 °C

4: 90 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

5: 90 percent / zinc, AcOH / 1 h / Ambient temperature

6: 88 percent / H₂ / 10percent Pd-C / methanol / 12 h

7: 89 percent / NaH / benzene / 3 h / Ambient temperature

8: pyridine / 0.5 h / Ambient temperature

9: 84 percent / 2 h / Ambient temperature

10: various solvent(s) / 10 h / Heating

With pyridine; hydrogen; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; zinc; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; benzene;

Reference yield:

5-methoxy-1-(2-methyl-3-oxocyclohex-1-enylmethyl)-1,2-dihydrocyclobutabenzene (83637-54-1) → 3-methoxy-7-methyl-9-phenylthio-4bα,5,6,8a,9,10-hexahydro-6α,8aα-ethanophenanthren-8(7H)-one (83637-59-6,98115-44-7,98169-15-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / H₂ / 10percent Pd-C / methanol / 12 h

2: 89 percent / NaH / benzene / 3 h / Ambient temperature

3: pyridine / 0.5 h / Ambient temperature

4: 84 percent / 2 h / Ambient temperature

5: various solvent(s) / 10 h / Heating

With pyridine; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; benzene;

upstream raw materials:

5-methoxy-1-(2-methyl-3-oxo-4-phenylthiomethylenecyclohexylmethyl)-1,2-dihydrocyclobutabenzene

5-methoxybenzocyclobuten-1-yl toluene-p-sulphonate

5-methoxybenzocyclobut-1-enyl phenyl sulphide

5-methoxy-1-(2-methyl-3-oxocyclohexylmethyl)-1,2-dihydrocyclobutabenzene