(5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one

Base Information

• Chemical Name: (5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one
• CAS No.: 116003-08-8
• Molecular Formula: C₂₀H₂₆O₄
• Molecular Weight: 330.424
• Mol file: 116003-08-8.mol

Synonyms:

Chemical Property of (5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one

There total 3 articles about (5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.1%

ethylene deltenone (5571-36-8) → (5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one (39931-88-9,116003-08-8,39931-87-8)

Guidance literature:

With 1,1,1,3,3,3-hexachloro-propan-2-one; dihydrogen peroxide; In dichloromethane; for 72h;

DOI:10.1002/jlcr.2580361210

Reference yield: 68.0%

ethylene deltenone (5571-36-8) → (5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one (39931-88-9,116003-08-8,39931-87-8) + 3,3-(ethylenedioxy)-5β,10β-epoxyestra-9(11)-ene-17-one (39931-88-9)

Guidance literature:

With pyridine; dihydrogen peroxide; In dichloromethane; at 0 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.steroids.2019.02.013

Reference yield:

dihydrogen peroxide (7722-84-1) + ethylene deltenone (5571-36-8) → (5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one (39931-88-9,116003-08-8,39931-87-8) + 3,3-(ethylenedioxy)-5β,10β-epoxyestra-9(11)-ene-17-one (39931-88-9)

Guidance literature:

With pyridine; 1,1,1,3,3,3-hexachloro-propan-2-one; In dichloromethane; water; at 20 - 25 ℃; for 18h;

upstream raw materials:

ethylene deltenone

dihydrogen peroxide

Downstream raw materials:

3,3-ethylenedioxy-5α-hydroxy-11β-{4'-[1',1'-(ethylenedioxy)-ethyl]phenyl}-estr-9-ene-17-one

11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione

3,3-ethylenedioxy-5α-hydroxy-11β-[4-(methoxy)phenyl]-estr-9-en-17-one

3-ethylenedioxy-5α-hydroxy-11β-(4'-acetyl-phenyl)-estr-9-ene-17-one