11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione

Base Information

• Chemical Name: 11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione
• CAS No.: 478157-88-9
• Molecular Formula: C₃₀H₃₉NO₃
• Molecular Weight: 461.645
• Mol file: 478157-88-9.mol

Synonyms:11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione

Chemical Property of 11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione

There total 9 articles about 11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C35H53NO5Si → 11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione (478157-88-9) + 11-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-5(10)9(11)-diene-3,17-dione

Guidance literature:

With hydrogenchloride; In dichloromethane; at 0 - 5 ℃;

DOI:10.1016/j.tetlet.2003.11.028

Reference yield:

4-(2-(diethylamino)ethoxy)bromobenzene (1823-62-7) + C23H36O4Si → 11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione (478157-88-9) + 11α-(4-(2-(dietylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione + 11-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-5(10)9(11)-diene-3,17-dione

Guidance literature:

4-(2-(diethylamino)ethoxy)bromobenzene; C₂₃H₃₆O₄Si; With copper(l) chloride; In tetrahydrofuran; at 0 ℃;

With ammonium chloride; In dichloromethane; water; at 10 - 15 ℃; Further stages;

DOI:10.1021/op0341622

Reference yield:

4-bromo-phenol (106-41-2) → 11β-(4-(2-(diethylamino)ethoxy)-phenyl)-estra-4,9-diene-3,17-dione (478157-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane; water / 18 h / 25 - 35 °C

2.1: copper(l) chloride / tetrahydrofuran / 0 °C

2.2: 10 - 15 °C

With N-benzyl-N,N,N-triethylammonium chloride; copper(l) chloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/op0341622

upstream raw materials:

<4-<2-(diethylamino)ethoxy>phenyl>magnesium bromide

(5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one

3,3-(ethylenedioxy)-5β,10β-epoxyestra-9(11)-ene-17-one

ethylene deltenone

Downstream raw materials:

4-chloro-11β-(4-(2-(diethylamino)ethoxy)phenyl)estra-1,3,5(10)-trien-3-ol-17-one hydrochloride