11-(2-Methoxy-4-methylamino-phenyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester

Base Information

• Chemical Name: 11-(2-Methoxy-4-methylamino-phenyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester
• CAS No.: 123871-20-5
• Molecular Formula: C₃₁H₃₃N₃O₅
• Molecular Weight: 527.62
• Mol file: 123871-20-5.mol

Synonyms:

Chemical Property of 11-(2-Methoxy-4-methylamino-phenyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-(2-Methoxy-4-methylamino-phenyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester

There total 2 articles about 11-(2-Methoxy-4-methylamino-phenyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-N-methylaniline (14318-66-2) → 11-(2-Methoxy-4-methylamino-phenyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester (123871-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / K₂CO₃ / acetonitrile

2: 78 percent / CH₂Cl₂

3: 1.) Co₂(CO)8; 2.) trifluoroacetic acid / 1.) EtOAc; 2.) 25 deg C

With dicobalt octacarbonyl; potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1039/c39890000518

Reference yield:

3-methoxy-N-methyl-N-(prop-2-yn-1-yl)aniline (123871-18-1) → 11-(2-Methoxy-4-methylamino-phenyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester (123871-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / CH₂Cl₂

2: 1.) Co₂(CO)8; 2.) trifluoroacetic acid / 1.) EtOAc; 2.) 25 deg C

With dicobalt octacarbonyl; trifluoroacetic acid; In dichloromethane;

DOI:10.1039/c39890000518

Reference yield: 55.0%

formic acid (64-18-6) + 11-(2-Methoxy-4-methylamino-phenyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester (123871-20-5) → 11-[4-(Formyl-methyl-amino)-2-methoxy-phenyl]-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-phenyl ester

Guidance literature:

In acetic anhydride;

DOI:10.1039/c39890000518

upstream raw materials:

3-methoxy-N-methylaniline

3-methoxy-N-methyl-N-(prop-2-yn-1-yl)aniline