((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-{(1R,2R)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-cyclopropyl}-methanone

Base Information

• Chemical Name: ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-{(1R,2R)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-cyclopropyl}-methanone
• CAS No.: 156338-64-6
• Molecular Formula: C₂₄H₃₁NO₅S
• Molecular Weight: 445.58

Synonyms:

Chemical Property of ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-{(1R,2R)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-cyclopropyl}-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-{(1R,2R)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-cyclopropyl}-methanone

There total 6 articles about ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-{(1R,2R)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-cyclopropyl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-propenone (157604-03-0) → ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-{(1R,2R)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-cyclopropyl}-methanone (156338-64-6)

Guidance literature:

With palladium diacetate; In dichloromethane; at 0 - 5 ℃; for 3h;

Reference yield:

2-bromophenyl methyl ketone (2142-69-0) → ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-{(1R,2R)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-cyclopropyl}-methanone (156338-64-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 88 percent / Et₃N, Pd(OAc)2, tri-o-tolylphosphine / 24 h / 100 °C

2: 93 percent / toluene-4-sulfonic acid / benzene / 14 h

3: 98 percent / NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

4: oxalyl chloride / toluene / 5 h / 50 °C

5: 1.) NaH / 1) toluene, 30 min; 2) toluene, overnight

6: 18 percent / Pd(OAc)2 / CH₂Cl₂ / 3 h / 0 - 5 °C

With palladium diacetate; sodium hydroxide; oxalyl dichloride; sodium hydride; toluene-4-sulfonic acid; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; dichloromethane; toluene; benzene;

Reference yield:

(E)-3-(2-acetyl-phenyl)-acrylic acid methyl ester (112212-88-1) → ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-{(1R,2R)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-cyclopropyl}-methanone (156338-64-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / toluene-4-sulfonic acid / benzene / 14 h

2: 98 percent / NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature

3: oxalyl chloride / toluene / 5 h / 50 °C

4: 1.) NaH / 1) toluene, 30 min; 2) toluene, overnight

5: 18 percent / Pd(OAc)2 / CH₂Cl₂ / 3 h / 0 - 5 °C

With palladium diacetate; sodium hydroxide; oxalyl dichloride; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; toluene; benzene;

upstream raw materials:

diazomethane

(E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-propenone

2-bromophenyl methyl ketone

(E)-3-(2-acetyl-phenyl)-acrylic acid methyl ester

Downstream raw materials:

(1R,2R)-2-(2-acetylphenyl)cyclopropane carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 156338-64-6 ((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-{(1R,2R)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-cyclopropyl}-methanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send