2-(benzylamino)-3-methylbutanoic acid

Base Information

• Chemical Name: 2-(benzylamino)-3-methylbutanoic acid
• CAS No.: 16975-39-6
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 16975-39-6.mol

Synonyms:

Chemical Property of 2-(benzylamino)-3-methylbutanoic acid

Chemical Property:

• Boiling Point: 335.4±25.0 °C(Predicted)
• PKA: 2.37±0.13(Predicted)
• Density: 1.076±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-(BENZYLAMINO)-3-METHYLBUTANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(benzylamino)-3-methylbutanoic acid

There total 4 articles about 2-(benzylamino)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

benzaldehyde (100-52-7) + D,L-valine (516-06-3,25609-85-2,7004-03-7,921-10-8) → 2-(benzylamino)-3-methylbutanoic acid (16975-39-6,15363-84-5,22711-77-9,98575-68-9)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; at 20 ℃;

DOI:10.1002/anie.200504116

Reference yield: 48.0%

→ 2-(benzylamino)-3-methylbutanoic acid (16975-39-6,15363-84-5,22711-77-9,98575-68-9)

Guidance literature:

With methanol; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield:

isobutylidenebenzylamine (22483-21-2) + carbon dioxide (124-38-9,18923-20-1) → C22H32N2 (1402136-60-0) + C22H32N2 + 2-(benzylamino)-3-methylbutanoic acid (16975-39-6,15363-84-5,22711-77-9,98575-68-9) + benzyl(2-methylpropyl)amine (42882-36-0)

Guidance literature:

isobutylidenebenzylamine; carbon dioxide; With samarium diiodide; In tetrahydrofuran; at 20 ℃; for 16h; under 37503.8 Torr; Autoclave;

With trifluoroacetic acid; In tetrahydrofuran; water;

DOI:10.1002/ejoc.201200440

upstream raw materials:

benzaldehyde

D,L-valine

N-(2-methylpropylidene)benzylamine-N-oxide

carbon dioxide

Downstream raw materials:

N-Acetoacetyl-N-benzyl-valin

(S)-2-(benzylamino)-3-methylbutanoic acid

[1-[benzyl(4-cyanobenzyl)amino]-2-methylpropyl]phosphonic acid diethyl ester

diethyl [1-(dibenzylamino)-2-methylpropyl]phosphonate