KNI-10074

Base Information

• Chemical Name: KNI-10074
• CAS No.: 1093409-12-1
• Molecular Formula: C₃₃H₃₅Cl₂N₃O₆S
• Molecular Weight: 672.629
• Mol file: 1093409-12-1.mol

Synonyms:

Chemical Property of KNI-10074

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of KNI-10074

There total 2 articles about KNI-10074 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride (1093076-74-4) + 2,6-dichlorophenoxyacetic acid (575-90-6) → KNI-10074 (1093409-12-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

DOI:10.1016/j.bmc.2008.10.011

Reference yield:

C25H31N3O4S (819083-90-4) + 2,6-dichlorophenoxyacetic acid (575-90-6) → KNI-10074 (1093409-12-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;

DOI:10.1111/j.1747-0285.2009.00921.x

upstream raw materials:

(R)-N-[(1S,2R)-2-hydroxyindan-1-yl]-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide hydrochloride

2,6-dichlorophenoxyacetic acid

C₂₅H₃₁N₃O₄S

Refernces

• 1、 Hidaka, Koushi,Kimura, Tooru,Ruben, Adam J.,Uemura, Tsuyoshi,Kamiya, Mami,Kiso, Aiko,Okamoto, Tetsuya,Tsuchiya, Yumi,Hayashi, Yoshio,Freire, Ernesto,Kiso, Yoshiaki. "Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin". experimental part. p. 10049 - 10060. Retrieved 2009/04/07.