575-90-6

Basic information

• Product Name: 2,6-D ACID
• Synonyms: 2,6-D ACID;Acetic acid, (2,6-dichlorophenoxy)-;2-(2,6-Dichlorophenoxy)acetic acid
• CAS NO: 575-90-6
• Molecular Formula: C₈H₆Cl₂O₃
• Molecular Weight: 221
• EINECS: 209-395-6
• Mol File: 575-90-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 134.5-135 °C
• Boiling Point: 316.96°C (rough estimate)
• Flash Point: 161.1°C
• Appearance: /
• Density: 1.4564 (rough estimate)
• Vapor Pressure: 2.84E-05mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.95±0.10(Predicted)
• Water Solubility: 1.558g/L(25 oC)
• CAS DataBase Reference: 2,6-D ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-D ACID(575-90-6)
• EPA Substance Registry System: 2,6-D ACID(575-90-6)

Safety Data

• Hazardous Substances Data: 575-90-6(Hazardous Substances Data)

Usage

General Description

2,6-D ACID, also known as 2,6-dichloroindophenol, is a chemical compound commonly used in chemistry and biochemistry as an indicator for the presence of ascorbic acid. It is a blue dye that turns colorless in the presence of ascorbic acid and is widely used in laboratory settings to measure the concentration of vitamin C in various substances. 2,6-D ACID is highly water-soluble and stable when stored properly, making it suitable for use in various analytical procedures. Its ability to accurately measure ascorbic acid levels has made it a valuable tool in the fields of nutrition, pharmaceuticals, and clinical research. Additionally, due to its stable nature and reliable performance, 2,6-D ACID is also used in quality control processes for food and beverage industries to ensure the accuracy of vitamin C content in their products.

InChI:InChI=1/C8H6Cl2O3/c9-5-2-1-3-6(10)8(5)13-4-7(11)12/h1-3H,4H2,(H,11,12)/p-1

Upstream product

• 87-65-0 2,6-Dichlorophenol 
• 79-11-8 chloroacetic acid 
• 40311-72-6 2,6-dichlorophenoxyacetic acid ethyl ester 
• 1928-49-0 methyl 2,6-dichlorophenoxyacetate 
• 105-36-2 ethyl bromoacetate 
• 626239-03-0 N-(2,4-dichloro-phenyl)-2-hydroxy-N-phenyl-acetamide 
• 774-74-3 2-(2,4-dichlorophenoxy)acetyl chloride 
• 626239-02-9 2-Chloro-N-(2,4-dichloro-phenyl)-N-phenyl-acetamide 
• 58373-59-4 2,4-dichloro-N-phenylaniline 
• 94-75-7 2,4-Dichlorophenoxyacetic acid 
• 13246-96-3 2,4-Dichlorophenoxyacetanilide 
• 352353-17-4 N-(2-acetyl-phenyl)-2-(2,6-dichloro-phenoxy)-acetamide 
• 79-08-3 bromoacetic acid 
• 120-67-2 2-(2,4-dichlorophenoxy)ethanol 

Downstream Products

• 1093409-12-1 KNI-10074 
• 900502-10-5 C₁₆H₁₆Cl₂NO₅P 
• 904702-60-9 O,O-dimethyl α-(2,6-dichlorophenoxyacetoxy)-3-nitrobenzylphosphonate 
• 119423-40-4 5'-[2-(2,6-dichlorophenoxy)acetamido]-2',5'-dideoxy-5-ethyluridine 
• 20143-46-8 (2,6-dichlorophenoxy)-acetyl chloride 

Relevant articles and documents

An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. As a continuous work to discover novel crop selective HPPD inhibitor, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using N,N′-carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH2Cl2. A total of 58 triketone compounds were synthesized in good to excellent yields. Some of the triketones displayed potent in vitro Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one, II-13, displayed high, broad-spectrum, and postemergent herbicidal activity at the dosage of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, II-13 showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that II-13 might have potential as a herbicide for weed control in maize and canola fields. II-13 is the first HPPD inhibitor showing good crop safety toward canola.

1,3,4-Thiadiazol-2-amine Derivatives as Urotensin-II Receptor (UT) Antagonists

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Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin

Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-dimethylthioproline scaffold to exhibit potent inhibitory activities against Plm II. Their activities against Plasmodium falciparum in the infected erythrocyte assay were largely different from those against the target enzyme. To improve the antimalarial activity of peptidomimetic Plm inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified alkylamino compounds such as 44 (KNI-10283) and 47 (KNI-10538) with more than 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining their potent Plm II inhibitory activity and low cytotoxicity. These results suggest that auxiliary substituents on a specific basic group contribute to deliver the inhibitors to the target Plm.