C₁₉H₁₇NO₄

Base Information

• Chemical Name: C₁₉H₁₇NO₄
• CAS No.: 127766-61-4
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.348
• Mol file: 127766-61-4.mol

Synonyms:

Chemical Property of C₁₉H₁₇NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₇NO₄

There total 18 articles about C₁₉H₁₇NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) → C19H17NO4 (127766-61-4,127995-48-6,133099-18-0)

Guidance literature:

Multi-step reaction with 18 steps

1: HNO₂, NaN₃

2: PCC

3: NaOH

4: 100 percent / n-Bu₄NF / tetrahydrofuran / -78 °C

5: 85 percent / BF₃-Et₂O / CH₂Cl₂

6: 81 percent / ethanol

7: 91 percent / Ph₃P, AcOH / methanol; tetrahydrofuran / 23 °C

8: 1.) DIBAL, 2.) NaBH₃CN, TFA / 1.) CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂

9: pyridine / CH₂Cl₂

10: pyridine

11: 99 percent / HgCl₂ / methanol / Heating

12: MCPBA / CH₂Cl₂

13: toluene / 175 °C

14: 70 percent / NaOH/H₂O / methanol / Heating

15: 89 percent / 2-(phenylsulfonyl)-3-phenyloxaziridine (Davis' reagent) / tetrahydrofuran / 23 °C

16: 85 percent / 23 °C

17: 78 percent / MCPBA, NaHCO₃ / CH₂Cl₂ / 23 °C

18: 1.) (COCl)2, Et₃N, 2.) H₂NNH₂ / 1.) DMSO, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, 0 deg C

With pyridine; sodium hydroxide; sodium azide; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; cis-nitrous acid; diisobutylaluminium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; N-(benzenesulfonyl)-3-phenyloxaziridine; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; mercury dichloride; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

DOI:10.1016/S0040-4039(01)89002-X

Reference yield:

(E)-3-(2-azidophenyl)-1-phenylprop-2-en-1-one (33037-74-0) → C19H17NO4 (127766-61-4,127995-48-6,133099-18-0)

Guidance literature:

Multi-step reaction with 15 steps

1: 100 percent / n-Bu₄NF / tetrahydrofuran / -78 °C

2: 85 percent / BF₃-Et₂O / CH₂Cl₂

3: 81 percent / ethanol

4: 91 percent / Ph₃P, AcOH / methanol; tetrahydrofuran / 23 °C

5: 1.) DIBAL, 2.) NaBH₃CN, TFA / 1.) CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂

6: pyridine / CH₂Cl₂

7: pyridine

8: 99 percent / HgCl₂ / methanol / Heating

9: MCPBA / CH₂Cl₂

10: toluene / 175 °C

11: 70 percent / NaOH/H₂O / methanol / Heating

12: 89 percent / 2-(phenylsulfonyl)-3-phenyloxaziridine (Davis' reagent) / tetrahydrofuran / 23 °C

13: 85 percent / 23 °C

14: 78 percent / MCPBA, NaHCO₃ / CH₂Cl₂ / 23 °C

15: 1.) (COCl)2, Et₃N, 2.) H₂NNH₂ / 1.) DMSO, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, 0 deg C

With pyridine; sodium hydroxide; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; diisobutylaluminium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; N-(benzenesulfonyl)-3-phenyloxaziridine; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid; mercury dichloride; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

DOI:10.1016/S0040-4039(01)89002-X

Reference yield:

2-azidobenzyl alcohol (20615-76-3) → C19H17NO4 (127766-61-4,127995-48-6,133099-18-0)

Guidance literature:

Multi-step reaction with 17 steps

1: PCC

2: NaOH

3: 100 percent / n-Bu₄NF / tetrahydrofuran / -78 °C

4: 85 percent / BF₃-Et₂O / CH₂Cl₂

5: 81 percent / ethanol

6: 91 percent / Ph₃P, AcOH / methanol; tetrahydrofuran / 23 °C

7: 1.) DIBAL, 2.) NaBH₃CN, TFA / 1.) CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂

8: pyridine / CH₂Cl₂

9: pyridine

10: 99 percent / HgCl₂ / methanol / Heating

11: MCPBA / CH₂Cl₂

12: toluene / 175 °C

13: 70 percent / NaOH/H₂O / methanol / Heating

14: 89 percent / 2-(phenylsulfonyl)-3-phenyloxaziridine (Davis' reagent) / tetrahydrofuran / 23 °C

15: 85 percent / 23 °C

16: 78 percent / MCPBA, NaHCO₃ / CH₂Cl₂ / 23 °C

17: 1.) (COCl)2, Et₃N, 2.) H₂NNH₂ / 1.) DMSO, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, 0 deg C

With pyridine; sodium hydroxide; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; diisobutylaluminium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; N-(benzenesulfonyl)-3-phenyloxaziridine; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; mercury dichloride; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

DOI:10.1016/S0040-4039(01)89002-X

upstream raw materials:

Acetic acid (1aS,8R,9S,9aR)-9-hydroxy-8-(2-oxo-2-phenyl-ethyl)-1a,8,9,9a-tetrahydro-2H-1-oxa-3-aza-benzo[a]cyclopropa[e]cycloocten-3-yl ester

2-Aminobenzyl alcohol

(E)-3-(2-azidophenyl)-1-phenylprop-2-en-1-one

2-azidobenzyl alcohol

Downstream raw materials:

C₁₉H₁₅NO₃