Technology Process of N-cyclopropyl-2-methyl-4-{6-(pyridin-4-yl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}benzamide
There total 12 articles about N-cyclopropyl-2-methyl-4-{6-(pyridin-4-yl)-4-[(3,3,3-trifluoropropyl)amino]-1H-benzimidazol-1-yl}benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: bromine; acetic acid
2.1: hydrogenchloride; tin(II) chloride dihdyrate / water / -20 - 20 °C
2.2: pH 10
3.1: hydrogenchloride / 20 °C / Reflux
3.2: pH 8
4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C
4.2: 3 °C
5.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 48 h / 23 °C
6.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one; water / 0.67 h / 140 °C / Microwave irradiation
With
pyridine; pyridine N-oxide; hydrogenchloride; tin(II) chloride dihdyrate; bromine; copper diacetate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1-methyl-pyrrolidin-2-one; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; tin(II) chloride dihdyrate / water / -20 - 20 °C
1.2: pH 10
2.1: hydrogenchloride / 20 °C / Reflux
2.2: pH 8
3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 23 °C
3.2: 3 °C
4.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 48 h / 23 °C
5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one; water / 0.67 h / 140 °C / Microwave irradiation
With
pyridine; pyridine N-oxide; hydrogenchloride; tin(II) chloride dihdyrate; copper diacetate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1-methyl-pyrrolidin-2-one; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / 20 °C / Reflux
1.2: pH 8
2.1: pyridine N-oxide; pyridine; copper diacetate / dichloromethane / 20 - 40 °C / Inert atmosphere
3.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C
4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one; water / 0.67 h / 140 °C / Microwave irradiation
With
pyridine; pyridine N-oxide; hydrogenchloride; copper diacetate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1-methyl-pyrrolidin-2-one; dichloromethane; water; 1,2-dichloro-ethane;
