Technology Process of 3-(Dimethylthexylsiloxy)-3-phenyl-2-(trimethylsiloxy)propannitril
There total 4 articles about 3-(Dimethylthexylsiloxy)-3-phenyl-2-(trimethylsiloxy)propannitril which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / conc.H2SO4 / 1) 3 d, r.t., 2) 4 h, reflux
2: 83 percent / NaI, pyridine / acetonitrile / Ambient temperature
3: 1) (iBu)2AlH (5), 2) conc.HCl/MeOH / 1) hexane, toluene, 20 h, r.t, 2) a) -78 degC, 15 min, b) r.t.
4: ZnI2 / CH2Cl2 / 17 h / Ambient temperature
With
pyridine; hydrogenchloride; methanol; sulfuric acid; diisobutylaluminium hydride; sodium iodide;
zinc(II) iodide;
In
dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 83 percent / NaI, pyridine / acetonitrile / Ambient temperature
2: 1) (iBu)2AlH (5), 2) conc.HCl/MeOH / 1) hexane, toluene, 20 h, r.t, 2) a) -78 degC, 15 min, b) r.t.
3: ZnI2 / CH2Cl2 / 17 h / Ambient temperature
With
pyridine; hydrogenchloride; methanol; diisobutylaluminium hydride; sodium iodide;
zinc(II) iodide;
In
dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) (iBu)2AlH (5), 2) conc.HCl/MeOH / 1) hexane, toluene, 20 h, r.t, 2) a) -78 degC, 15 min, b) r.t.
2: ZnI2 / CH2Cl2 / 17 h / Ambient temperature
With
hydrogenchloride; methanol; diisobutylaluminium hydride;
zinc(II) iodide;
In
dichloromethane;
