(R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

• Chemical Name: (R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS No.: 145207-50-7
• Molecular Formula: C₂₈H₃₃NO₆
• Molecular Weight: 479.573
• Mol file: 145207-50-7.mol

Synonyms:

Chemical Property of (R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 3 articles about (R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

l-menthyl phenylglyoxylate (20229-41-8) → (R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (145207-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / p-TsOH

2: Ac₂O

With acetic anhydride; toluene-4-sulfonic acid;

DOI:10.1248/cpb.40.1972

Reference yield:

4-methoxy-aniline (104-94-9) → (R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (145207-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / p-TsOH

2: Ac₂O

With acetic anhydride; toluene-4-sulfonic acid;

DOI:10.1248/cpb.40.1972

Reference yield:

malonic acid (141-82-2) + [(E)-4-Methoxy-phenylimino]-phenyl-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (145207-46-1) → (R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (145207-50-7)

Guidance literature:

With acetic anhydride; Yield given. Yields of byproduct given;

DOI:10.1248/cpb.40.1972

upstream raw materials:

malonic acid

[(E)-4-Methoxy-phenylimino]-phenyl-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

l-menthyl phenylglyoxylate

4-methoxy-aniline

Downstream raw materials:

(S)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-5-((S)-1-phenyl-propyl)-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

(R)-4-(4-Methoxy-phenylcarbamoyl)-3-phenyl-butyric acid ethyl ester

(R)-3-(4-Methoxy-phenyl)-4,6-dioxo-2-phenyl-5-[1-phenyl-meth-(Z)-ylidene]-[1,3]oxazinane-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester