2-(1'-phenylethyl)-3-paramethoxyphenyloxaziridine

Base Information

• Chemical Name: 2-(1'-phenylethyl)-3-paramethoxyphenyloxaziridine
• CAS No.: 102302-75-0
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.316
• Mol file: 102302-75-0.mol

Synonyms:

Chemical Property of 2-(1'-phenylethyl)-3-paramethoxyphenyloxaziridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1'-phenylethyl)-3-paramethoxyphenyloxaziridine

There total 4 articles about 2-(1'-phenylethyl)-3-paramethoxyphenyloxaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(4-methoxybenzylidene)-α-methylbenzylamine (82319-42-4,135820-59-6,74879-40-6) → 2-(1'-phenylethyl)-3-paramethoxyphenyloxaziridine (102302-75-0,1094728-03-6,1094728-04-7,1094728-17-2,1094728-19-4) + C16H17NO2

Guidance literature:

With dihydrogen peroxide; sodium hydrogencarbonate; (2S)-2-bromo-4-methylpentanenitrile; In dichloromethane; at 0 - 25 ℃; pH=8; optical yield given as %de; diastereoselective reaction;

DOI:10.1080/00397911.2011.573611

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → 2-(1'-phenylethyl)-3-paramethoxyphenyloxaziridine (102302-75-0,1094728-03-6,1094728-04-7,1094728-17-2,1094728-19-4) + C16H17NO2

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 48 h / 20 - 25 °C / Molecular sieve

2: dihydrogen peroxide; sodium hydrogencarbonate; (2S)-2-bromo-4-methylpentanenitrile / dichloromethane / 0 - 25 °C / pH 8

With dihydrogen peroxide; sodium hydrogencarbonate; (2S)-2-bromo-4-methylpentanenitrile; In dichloromethane;

DOI:10.1080/00397911.2011.573611

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 2-(1'-phenylethyl)-3-paramethoxyphenyloxaziridine (102302-75-0,1094728-03-6,1094728-04-7,1094728-17-2,1094728-19-4) + C16H17NO2

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 48 h / 20 - 25 °C / Molecular sieve

2: dihydrogen peroxide; sodium hydrogencarbonate; (2S)-2-bromo-4-methylpentanenitrile / dichloromethane / 0 - 25 °C / pH 8

With dihydrogen peroxide; sodium hydrogencarbonate; (2S)-2-bromo-4-methylpentanenitrile; In dichloromethane;

DOI:10.1080/00397911.2011.573611

upstream raw materials:

(S)-1-phenyl-ethylamine

4-methoxy-benzaldehyde

(S)-N-(4-methoxybenzylidene)-α-methylbenzylamine

Downstream raw materials:

(3aS,6aR)-3,3-Dimethyl-1-((S)-1-phenyl-ethyl)-tetrahydro-furo[3,2-c]isoxazol-5-one

(3aR,6aS)-3,3-Dimethyl-1-((S)-1-phenyl-ethyl)-tetrahydro-furo[3,2-c]isoxazol-5-one

(3R,3aR,6aS)-3-Methyl-1-((S)-1-phenyl-ethyl)-tetrahydro-furo[3,2-c]isoxazol-5-one

(3R,3aS,6aR)-3-Methyl-1-((S)-1-phenyl-ethyl)-tetrahydro-furo[3,2-c]isoxazol-5-one