1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione
CAS No.:809232-63-1
Molecular Formula:C₃₆H₄₉FN₄O₇S₂
Molecular Weight:732.938
Hs Code.:

1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione

There total 7 articles about 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10212-13-2
3’,5’-O-acetyl-2’-deoxy-2’-fluorouridine

: 809232-63-1
1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: iodonium chloride / CH₂Cl₂

2: (CH₃CN)2PdCl₂ / dimethylformamide

3: NBS; triphenylphosphorus / dimethylformamide

4: DIEA / acetonitrile

5: potassium carbonate / aq. methanol

With N-Bromosuccinimide; iodonium chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2004.09.145

Reference yield:

: 56287-17-3,69123-94-0,784-71-4
2'-deoxy-2'-fluorouridine

: 809232-63-1
1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine

2: iodonium chloride / CH₂Cl₂

3: (CH₃CN)2PdCl₂ / dimethylformamide

4: NBS; triphenylphosphorus / dimethylformamide

5: DIEA / acetonitrile

6: potassium carbonate / aq. methanol

With pyridine; N-Bromosuccinimide; iodonium chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2004.09.145

Reference yield:

: 565226-18-8
((2R,3R,4R,5R)-3-acetoxy-4-fluoro-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate

: 809232-63-1
1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-[(E)-5-([2-(4-methoxy-benzylsulfanyl)-ethyl]-{2-[2-(4-methoxy-benzylsulfanyl)-ethylamino]-ethyl}-amino)-pent-1-enyl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: (CH₃CN)2PdCl₂ / dimethylformamide

2: NBS; triphenylphosphorus / dimethylformamide

3: DIEA / acetonitrile

4: potassium carbonate / aq. methanol

With N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetlet.2004.09.145