1,1-Difluoro-4-methoxycyclohexan

Base Information

• Chemical Name: 1,1-Difluoro-4-methoxycyclohexan
• CAS No.: 27371-43-3
• Molecular Formula: C₇H₁₂F₂O
• Molecular Weight: 150.168
• Mol file: 27371-43-3.mol

Synonyms:

Chemical Property of 1,1-Difluoro-4-methoxycyclohexan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-Difluoro-4-methoxycyclohexan

There total 2 articles about 1,1-Difluoro-4-methoxycyclohexan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxycyclohexanone (13482-23-0) → 1,1-Difluoro-4-methoxycyclohexan (27371-43-3)

Guidance literature:

With sulfur tetrafluoride; hydrogen fluoride; In dichloromethane;

DOI:10.1021/jo00805a019

Reference yield:

4-methoxycyclohexan-1-ol (18068-06-9) → 1,1-Difluoro-4-methoxycyclohexan (27371-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: CrO₃

2: HF, SF₄ / CH₂Cl₂

With chromium(VI) oxide; sulfur tetrafluoride; hydrogen fluoride; In dichloromethane;

DOI:10.1021/jo00805a019

Reference yield:

1,1-Difluoro-4-methoxycyclohexan (27371-43-3) → 4-Methoxy-1-fluoro-cyclohexen (27415-47-0)

Guidance literature:

With aluminum oxide; In hexane;

DOI:10.1021/jo00805a019

upstream raw materials:

4-methoxycyclohexanone

4-methoxycyclohexan-1-ol

Downstream raw materials:

4-Methoxy-1-fluoro-cyclohexen