N-Isopropyl-2-{3-[3-(3-methylsulfanyl-phenyl)-ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-N-phenyl-acetamide

Base Information

• Chemical Name: N-Isopropyl-2-{3-[3-(3-methylsulfanyl-phenyl)-ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-N-phenyl-acetamide
• CAS No.: 184945-07-1
• Molecular Formula: C₃₄H₃₃N₅O₄S
• Molecular Weight: 607.733
• Mol file: 184945-07-1.mol

Synonyms:

Chemical Property of N-Isopropyl-2-{3-[3-(3-methylsulfanyl-phenyl)-ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-N-phenyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Isopropyl-2-{3-[3-(3-methylsulfanyl-phenyl)-ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-N-phenyl-acetamide

There total 5 articles about N-Isopropyl-2-{3-[3-(3-methylsulfanyl-phenyl)-ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-N-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-N-isopropyl-N-phenyl-acetamide (161455-97-6) → N-Isopropyl-2-{3-[3-(3-methylsulfanyl-phenyl)-ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-N-phenyl-acetamide (184945-07-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 10.0 g / K₂CO₃ / dimethylformamide

2: 7.5 g / tetrahydrofuran / 4 h / Ambient temperature

3: 6.3 g / Zn, glacial AcOH / 1 h / Ambient temperature

4: 220.6 mg / CH₂Cl₂ / 12 h

With potassium carbonate; acetic acid; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm9601664

Reference yield:

N-isopropyl-N-phenyl-2-(2-phenylamino-phenylamino)-acetamide (161455-90-9) → N-Isopropyl-2-{3-[3-(3-methylsulfanyl-phenyl)-ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-N-phenyl-acetamide (184945-07-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 7.5 g / tetrahydrofuran / 4 h / Ambient temperature

2: 6.3 g / Zn, glacial AcOH / 1 h / Ambient temperature

3: 220.6 mg / CH₂Cl₂ / 12 h

With acetic acid; zinc; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm9601664

Reference yield:

2-[2,4-Dioxo-5-phenyl-3-(phenyl-hydrazono)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide (161455-91-0) → N-Isopropyl-2-{3-[3-(3-methylsulfanyl-phenyl)-ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl}-N-phenyl-acetamide (184945-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 6.3 g / Zn, glacial AcOH / 1 h / Ambient temperature

2: 220.6 mg / CH₂Cl₂ / 12 h

With acetic acid; zinc; In dichloromethane;

DOI:10.1021/jm9601664

upstream raw materials:

3-(methylthio)phenyl isocyanate

2-(3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenylacetamide

2-bromo-N-isopropyl-N-phenyl-acetamide

N-isopropyl-N-phenyl-2-(2-phenylamino-phenylamino)-acetamide