2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid (2-{2-[(2-{2-[(2-{2-[(2-mercapto-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethyl)-amide

Base Information

• Chemical Name: 2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid (2-{2-[(2-{2-[(2-{2-[(2-mercapto-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethyl)-amide
• CAS No.: 926646-70-0
• Molecular Formula: C₄₆H₆₂N₁₀O₁₁S
• Molecular Weight: 963.125
• Mol file: 926646-70-0.mol

Synonyms:

Chemical Property of 2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid (2-{2-[(2-{2-[(2-{2-[(2-mercapto-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid (2-{2-[(2-{2-[(2-{2-[(2-mercapto-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethyl)-amide

There total 1 articles about 2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid (2-{2-[(2-{2-[(2-{2-[(2-mercapto-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid (874301-24-3) + 8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid (166108-71-0,675606-79-8) → 2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid (2-{2-[(2-{2-[(2-{2-[(2-mercapto-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethyl)-amide (926646-70-0)

Guidance literature:

Multistep reaction;

DOI:10.1016/j.bmcl.2006.09.089

Reference yield:

2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid (2-{2-[(2-{2-[(2-{2-[(2-mercapto-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethyl)-amide (926646-70-0) + methyl iodide (74-88-4) → 2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid (2-{2-[(2-{2-[(2-{2-[(2-methylsulfanyl-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethyl)-amide

Guidance literature:

With triethylamine; In methanol;

DOI:10.1016/j.bmcl.2006.09.089

Reference yield:

2'-(4-hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-1H,3'H-[2,5']bibenzoimidazolyl-4-carboxylic acid (2-{2-[(2-{2-[(2-{2-[(2-mercapto-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethylcarbamoyl)-methoxy]-ethoxy}-ethyl)-amide (926646-70-0) + GLUTATHIONE (70-18-8) → C56H77N13O17S2

Guidance literature:

With GSSG;

DOI:10.1016/j.bmcl.2006.09.089

upstream raw materials:

2'-(4-hydroxyphenyl)-6-(4-methylpiperazin-1-yl)-1H,3'H-2,5'-bibenzoimidazoyl-4-carboxylic acid

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid