6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

Base Information

Chemical Name:6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide
CAS No.:1293979-87-9
Molecular Formula:C₃₅H₃₆BF₂N₅O₂S
Molecular Weight:639.577
Hs Code.:

6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

Synonyms:

Suppliers and Price of 6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

There total 12 articles about 6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 4-(((4-methoxyphenyl)diphenylmethylthio)methyl)-oxazolidine-2,5-dione

: 1293979-85-7
6-(4-(tert-butoxycarbonylamino)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]-pyridin-2-ium-3-uide

: 1293979-87-9
6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; CF3SO3H was added dropwise to the complex in CH2Cl2, stirred for 3 h at ambient temp. under Ar, diluted with CH2Cl2, cooled (0°C), neutralized with N(C2H5)3, oxazolidine in CH2Cl2 was added dropwise, stirred for 3 h at 0°C to room temp.; diluted with CH2Cl2, washed with satd. NH4Cl, satd. NaHCO3 and H2O, dried over anhyd. Na2SO4, volatiles were evapd. under reduced pressure, silica gel column chromy. (CH3OH/CH2Cl2 (0-1%));
DOI:10.1021/ja2005175

Reference yield:

: 1293979-82-4
6-iodo-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

: 1293979-87-9
6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dichloromethane / 3.5 h

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: dichloromethane / 3.25 h / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja2005175

Reference yield:

: 77992-46-2
(5-iodopyridin-2-yl)hydrazine

: 1293979-87-9
6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1 h / 20 °C

2.1: boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 4 h / 20 - 90 °C / Inert atmosphere

3.1: potassium carbonate / dichloromethane / 3.5 h

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: dichloromethane / 3.25 h / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron trifluoride diethyl etherate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1021/ja2005175