Technology Process of 6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide
There total 12 articles about 6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
CF3SO3H was added dropwise to the complex in CH2Cl2, stirred for 3 h at ambient temp. under Ar, diluted with CH2Cl2, cooled (0°C), neutralized with N(C2H5)3, oxazolidine in CH2Cl2 was added dropwise, stirred for 3 h at 0°C to room temp.; diluted with CH2Cl2, washed with satd. NH4Cl, satd. NaHCO3 and H2O, dried over anhyd. Na2SO4, volatiles were evapd. under reduced pressure, silica gel column chromy. (CH3OH/CH2Cl2 (0-1%));
DOI:10.1021/ja2005175
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / dichloromethane / 3.5 h
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: dichloromethane / 3.25 h / 0 - 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/ja2005175
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1 h / 20 °C
2.1: boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 4 h / 20 - 90 °C / Inert atmosphere
3.1: potassium carbonate / dichloromethane / 3.5 h
4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere
5.2: Inert atmosphere
6.1: dichloromethane / 3.25 h / 0 - 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron trifluoride diethyl etherate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid;
In
dichloromethane; toluene;
DOI:10.1021/ja2005175
