Technology Process of 2,6-dichloro-5-(trifluoromethyl)nicotinonitrile
There total 3 articles about 2,6-dichloro-5-(trifluoromethyl)nicotinonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(trifluoromethyl)trimethylsilane;
With
potassium fluoride;
copper(l) iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 - 50 ℃;
for 21h;
2,6-dichloro-5-iodonicotinonitrile;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 50 ℃;
for 30h;
With
ammonia;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: phosphorus pentachloride; trichlorophosphate / Reflux
2.1: potassium fluoride / copper(l) iodide / tetrahydrofuran; N,N-dimethyl-formamide / 21 h / 20 - 50 °C
2.2: 30 h / 50 °C
With
potassium fluoride; phosphorus pentachloride; trichlorophosphate;
copper(l) iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-iodo-succinimide / dichloromethane / 0.33 h / 20 °C
2.1: phosphorus pentachloride; trichlorophosphate / Reflux
3.1: potassium fluoride / copper(l) iodide / tetrahydrofuran; N,N-dimethyl-formamide / 21 h / 20 - 50 °C
3.2: 30 h / 50 °C
With
potassium fluoride; N-iodo-succinimide; phosphorus pentachloride; trichlorophosphate;
copper(l) iodide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
