N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide

Base Information

Chemical Name:N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide
CAS No.:1239894-07-5
Molecular Formula:C₂₇H₂₈Cl₂F₃N₃O₃
Molecular Weight:570.439
Hs Code.:

N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide

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Chemical Property of N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide

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Technology Process of N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide

There total 8 articles about N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₆Cl₂F₃N₃O₅

: 1239894-07-5
N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 45 ℃;
DOI:10.1021/jm300122u

Reference yield:

: 1373527-64-0
(S)-ethyl 2-amino-3-(2,4-dichlorophenyl)propanoate hydrochloride

: 1239894-07-5
N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h / 20 °C

2.1: sodium hydroxide / methanol / 18 h / 20 °C

2.2: pH 3

3.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 18 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol / 45 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,4-dioxane; methanol; acetonitrile;
DOI:10.1021/jm300122u

Reference yield:

: 936727-93-4
1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid

: 1239894-07-5
N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h / 20 °C

2.1: sodium hydroxide / methanol / 18 h / 20 °C

2.2: pH 3

3.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 18 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol / 45 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,4-dioxane; methanol; acetonitrile;
DOI:10.1021/jm300122u