tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide disodium salt

Base Information

• Chemical Name: tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide disodium salt
• CAS No.: 105567-89-3
• Molecular Formula: C₅₈H₇₆N₁₀O₁₈S₃*2Na
• Molecular Weight: 1343.48
• Mol file: 105567-89-3.mol

Synonyms:

Chemical Property of tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide disodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide disodium salt

There total 4 articles about tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide disodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O4-sulfotyrosine α-methyl ester sodium salt (115967-23-2) + methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide trifluoroacetate (92409-86-4) → tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O4-sulfotyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide disodium salt (105567-89-3,115967-24-3)

Guidance literature:

With sodium hydroxide; ethylenediaminetetraacetic acid; papain; diothiothreitol; In methanol; at 30 ℃; for 0.333333h; pH 9.1;

Reference yield:

L-Tyr-OMe (1080-06-4) → tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O4-sulfotyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide disodium salt (105567-89-3,115967-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / DCC, hydroxybenzotriazole / dimethylformamide / 1) -10 to -5 deg C, 2 h; 2) r.t., overnight

2: 84 percent / pyridinium acetyl sulfate / dimethylformamide; pyridine / 20 h / 40 °C

3: 42 percent / ethylenediaminetetraacetic acid, dithiothreitol, papain, aq. NaOH / methanol / 0.33 h / 30 °C / pH 9.1

With sodium hydroxide; ethylenediaminetetraacetic acid; benzotriazol-1-ol; pyridinium acetyl sulfate; dicyclohexyl-carbodiimide; papain; diothiothreitol; In pyridine; methanol; N,N-dimethyl-formamide;

Reference yield:

Boc-Asp(OtBu)-OH (1676-90-0) → tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O4-sulfotyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide disodium salt (105567-89-3,115967-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / DCC, hydroxybenzotriazole / dimethylformamide / 1) -10 to -5 deg C, 2 h; 2) r.t., overnight

2: 84 percent / pyridinium acetyl sulfate / dimethylformamide; pyridine / 20 h / 40 °C

3: 42 percent / ethylenediaminetetraacetic acid, dithiothreitol, papain, aq. NaOH / methanol / 0.33 h / 30 °C / pH 9.1

With sodium hydroxide; ethylenediaminetetraacetic acid; benzotriazol-1-ol; pyridinium acetyl sulfate; dicyclohexyl-carbodiimide; papain; diothiothreitol; In pyridine; methanol; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosine α-methyl ester sodium salt

methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide trifluoroacetate

L-Tyr-OMe

Boc-Asp(OtBu)-OH

Downstream raw materials:

CCK-8