2--5-(5-nitro-3,4-diphenyl-2-furyl)-1,2,4-oxadiazole

Base Information

Chemical Name:2--5-(5-nitro-3,4-diphenyl-2-furyl)-1,2,4-oxadiazole
CAS No.:77720-37-7
Molecular Formula:C₂₀H₁₆N₄O₆
Molecular Weight:408.37
Hs Code.:

2-<bis(hydroxymethyl)amino>-5-(5-nitro-3,4-diphenyl-2-furyl)-1,2,4-oxadiazole

Synonyms:

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Chemical Property of 2--5-(5-nitro-3,4-diphenyl-2-furyl)-1,2,4-oxadiazole

Chemical Property:

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Technology Process of 2--5-(5-nitro-3,4-diphenyl-2-furyl)-1,2,4-oxadiazole

There total 7 articles about 2--5-(5-nitro-3,4-diphenyl-2-furyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 77720-36-6
2-amino-5-(5-nitro-3,4-diphenyl-2-furyl)-1,3,4-oxazole

: 77720-37-7
2--5-(5-nitro-3,4-diphenyl-2-furyl)-1,2,4-oxadiazole

Guidance literature:: In water; N,N-dimethyl-formamide; at 100 ℃; for 0.5h;
DOI:10.1248/cpb.29.635

Reference yield:

: 52101-36-7
methyl 3,4-diphenylfuran-2-carboxylate

: 77720-37-7
2--5-(5-nitro-3,4-diphenyl-2-furyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1: 20 percent / acetyl nitrate / 1.5 h / -30 °C

2: 92 percent / 2.5percent NaOH / dioxane / 0.5 h / Ambient temperature

3: 92 percent / SOCl₂ / 3 h / Heating

4: 60 percent / hydrazin hydrate / ethanol; benzene / 0.25 h / 0 - 3 °C

5: 75 percent / methanol / 1.5 h / Heating

6: 62 percent / dimethylformamide; H₂O / 0.5 h / 100 °C

With sodium hydroxide; thionyl chloride; nitro acetate; hydrazine hydrate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.29.635

Reference yield:

: 52101-40-3
5-nitro-3,4-diphenylfuran-2-carboxylic acid

: 77720-37-7
2--5-(5-nitro-3,4-diphenyl-2-furyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / SOCl₂ / 3 h / Heating

2: 60 percent / hydrazin hydrate / ethanol; benzene / 0.25 h / 0 - 3 °C

3: 75 percent / methanol / 1.5 h / Heating

4: 62 percent / dimethylformamide; H₂O / 0.5 h / 100 °C

With thionyl chloride; hydrazine hydrate; In methanol; ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.29.635