Technology Process of cis-2-(dimethylamino)-3-phenyl-5-tert-butyl-1,3,2-oxazaphosphorinane
There total 14 articles about cis-2-(dimethylamino)-3-phenyl-5-tert-butyl-1,3,2-oxazaphosphorinane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 93 percent Turnov. / potassium hydroxide / ethanol / 3 h / Heating
2: SOCl2 / 1.5 h / Heating
4: 95 percent / LiAlH4 / diethyl ether / 1.) room temperature, 6 h, 2.) reflux, 90 h
5: 61 percent / Et3N, PCl3 / diethyl ether / 1.) ice-bath temperature, 1.5 h, 2.) room temperature, 2 h
6: diethyl ether
With
potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; triethylamine; phosphorus trichloride;
In
diethyl ether; ethanol;
DOI:10.1021/ja00387a039
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 93 percent Turnov. / potassium hydroxide / ethanol / 3 h / Heating
2: SOCl2 / 1.5 h / Heating
4: 95 percent / LiAlH4 / diethyl ether / 1.) room temperature, 6 h, 2.) reflux, 90 h
5: 61 percent / Et3N, PCl3 / diethyl ether / 1.) ice-bath temperature, 1.5 h, 2.) room temperature, 2 h
6: diethyl ether
With
potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; triethylamine; phosphorus trichloride;
In
diethyl ether; ethanol;
DOI:10.1021/ja00387a039
- Guidance literature:
-
Multi-step reaction with 5 steps
1: SOCl2 / 1.5 h / Heating
3: 95 percent / LiAlH4 / diethyl ether / 1.) room temperature, 6 h, 2.) reflux, 90 h
4: 61 percent / Et3N, PCl3 / diethyl ether / 1.) ice-bath temperature, 1.5 h, 2.) room temperature, 2 h
5: diethyl ether
With
lithium aluminium tetrahydride; thionyl chloride; triethylamine; phosphorus trichloride;
In
diethyl ether;
DOI:10.1021/ja00387a039
