759-24-0Relevant articles and documents
Tautomerism in bis(oxazoline)s
Walli, Adam,Dechert, Sebastian,Meyer, Franc
, p. 7044 - 7049 (2013)
Bis(oxazoline)s (BOXs) are a privileged ligand class and have found widespread use in catalysis. Herein, the tautomerism of selected BOX ligands was evidenced by X-ray diffractometry as well as by NMR and IR spectroscopy and supported by DFT calculations. In CDCl3 solution at room temperature, the new 1,1-bis(4,4-dimethyl-1,3-oxazolin-2-yl)-1-phenylmethane ( Ph,HBOX-Me2) ligand is present as a 1:1 mixture of the diimine and iminoenamine tautomers. Thermodynamic and kinetic data for the tautomeric equilibrium were determined, which allowed comparison with related bidentate ligand classes. The other BOXs studied, H,HBOX-Me 2, Me,HBOX-Me2, and tBu,HBOX-Me 2, are largely present in the diimine form under similar conditions. IR spectroscopy was identified as a valuable tool for detecting the presence of the iminoenamine form as a minor component. Tautomerism in the prominent bis(oxazoline) ligand class is evidenced by X-ray diffractometry as well as by NMR and IR spectroscopy and supported by DFT calculations. Thermodynamic and kinetic data for the tautomeric equilibrium are determined for a specific example, which allows comparison with related bidentate ligand classes. Copyright
A amide alkaloid fully synthetic method
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Paragraph 0056; 0057, (2017/08/25)
The invention discloses a total synthesis method of amides alkaloid, and belongs to the technical field of the chemistry of natural products. The total synthesis method comprises the following steps: carrying out the synthesis by adopting malonate and 2-bromopropane or 2-bromopropane derivative as raw materials, thereby obtaining isopropyl malonate; (2) carrying out the synthesis by adopting 2-aminopyrrolidine as a raw material, thereby obtaining mid-body 2-amino tetralin pyrrolidine; and (3) synthesizing amides alkaloid 3-isopropyl-nafoxidine[1,2-alpha]pyrimidine-2,4(1H,3H)-diketone and a derivative by adopting the isopropyl malonate and the 2-2-amino tetralin pyrrolidine as a raw material. By adopting the total synthesis method, the defect that the extraction separation process in the natural product is complicated and the yield is low can be overcome, and the demand of perople for further researching the natural product can be satisfied; moreover, the synthesis method is simple in route, raw materials are cheap and easy to obtain, and the yield is relatively high.
METHOD OF PRODUCING 3-ETHOXY-2-TERT-BUTYL ALKYL PROPIONATE
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Paragraph 0039; 0040, (2016/12/22)
PROBLEM TO BE SOLVED: To provide a novel production method of 3-ethoxy-2-tert-butyl alkyl propionate used for the production of an olefin polymerization solid catalyst. SOLUTION: A 2-ethoxy methyl malonic acid diester derivative represented by formula (1) (where R1 and R2 represent a 1-4C alkyl group) is reacted in the presence of a base. COPYRIGHT: (C)2015,JPO&INPIT
