Technology Process of 2,4-Dimethoxy-7-methyl-16-phenylsulfanyl-7,8,9,10,13,14,15,16-octahydro-12H-6-oxa-benzocyclotetradecene-5,11-dione
There total 13 articles about 2,4-Dimethoxy-7-methyl-16-phenylsulfanyl-7,8,9,10,13,14,15,16-octahydro-12H-6-oxa-benzocyclotetradecene-5,11-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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-
84574-17-4
11-Hydroxy-2,4-dimethoxy-7-methyl-5-oxo-16-phenylsulfanyl-7,8,9,10,11,12,13,14,15,16-decahydro-5H-6-oxa-benzocyclotetradecene-11-carbonitrile
- Guidance literature:
-
With
sodium hydroxide;
In
diethyl ether;
at 0 ℃;
for 0.0166667h;
Yield given;
DOI:10.1016/S0040-4039(00)85600-2
- Guidance literature:
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Multi-step reaction with 10 steps
1: Pd
2: KN(SiMe3)2
3: KI / hexamethylphosphoric acid triamide
4: H2O, H(1+)
5: CrO3, pyridine
6: NaHSO3
7: H3O(1+)
8: 95 percent / NaN(SiMe3)2 / tetrahydrofuran / 0.5 h / 40 °C / reverse addition method
9: 3N HCl / tetrahydrofuran / 0 °C
10: 2percent NaOH / diethyl ether / 0.02 h / 0 °C
With
pyridine; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; oxonium; water; sodium hexamethyldisilazane; hydrogen cation; potassium hexamethylsilazane; sodium hydrogensulfite; potassium iodide;
palladium;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1016/S0040-4039(00)85600-2
- Guidance literature:
-
Multi-step reaction with 10 steps
1: Pd
2: KN(SiMe3)2
3: KI / hexamethylphosphoric acid triamide
4: H2O, H(1+)
5: CrO3, pyridine
6: NaHSO3
7: H3O(1+)
8: 95 percent / NaN(SiMe3)2 / tetrahydrofuran / 0.5 h / 40 °C / reverse addition method
9: 3N HCl / tetrahydrofuran / 0 °C
10: 2percent NaOH / diethyl ether / 0.02 h / 0 °C
With
pyridine; chromium(VI) oxide; hydrogenchloride; sodium hydroxide; oxonium; water; sodium hexamethyldisilazane; hydrogen cation; potassium hexamethylsilazane; sodium hydrogensulfite; potassium iodide;
palladium;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1016/S0040-4039(00)85600-2
