2-Methoxypropionyl chloride

Base Information

• Chemical Name: 2-Methoxypropionyl chloride
• CAS No.: 56680-75-2
• Molecular Formula: C4H7 Cl O2
• Molecular Weight: 122.551
• European Community (EC) Number: 260-332-9
• DSSTox Substance ID: DTXSID80972130
• Nikkaji Number: J267.082H
• Mol file: 56680-75-2.mol

Synonyms:2-methoxypropanoyl chloride;2-Methoxypropionyl chloride;56680-75-2;EINECS 260-332-9;SCHEMBL660278;2-Methoxypropanoic acid chloride;DTXSID80972130

Chemical Property of 2-Methoxypropionyl chloride

Chemical Property:

• Vapor Pressure: 13.8mmHg at 25°C
• Boiling Point: 122.6°Cat760mmHg
• Flash Point: 41.3°C
• PSA: 26.30000
• Density: 1.116g/cm³
• LogP: 0.78670
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 122.0134572
• Heavy Atom Count: 7
• Complexity: 72.1

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)Cl)OC

Technology Process of 2-Methoxypropionyl chloride

There total 2 articles about 2-Methoxypropionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methoxypropionic acid (4324-37-2) → 2-methoxypropanoyl chloride (56680-75-2)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1007/s10593-018-2286-y

Reference yield:

→ 2-methoxypropanoyl chloride (56680-75-2)

Guidance literature:

Reference yield: 98.0%

2-methoxypropanoyl chloride (56680-75-2) + carbon monoxide (201230-82-2) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → <(carbomethoxy)(2-methoxypropionyl)>methylenetriphenylphosphorane (139915-35-8)

Guidance literature:

With triethylamine; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/ja00037a008

upstream raw materials:

2-methoxypropionic acid

Downstream raw materials:

6-(1-methoxy-ethyl)-N²-phenyl-[1,3,5]triazine-2,4-diyldiamine

4'-methyl-2',6'-di-tert-butylphenyl (RS)-2-methoxypropanoate

2-Methoxy-N-((3S,4R)-3-methyl-1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide

2-Methoxy-N-((3R,4R)-3-methyl-1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide