2-Methoxypropanoic acid

Base Information

• Chemical Name: 2-Methoxypropanoic acid
• CAS No.: 4324-37-2
• Molecular Formula: C4H8O3
• Molecular Weight: 104.106
• Hs Code.: 2918990090
• European Community (EC) Number: 224-356-3
• UNII: 288B9CW12D
• DSSTox Substance ID: DTXSID6044018
• Nikkaji Number: J205.707G
• Wikidata: Q27254286
• Mol file: 4324-37-2.mol

Synonyms:2-methoxypropanoic acid;2-methoxypropanoic acid, (S)-isomer;2-methoxypropionic acid

Chemical Property of 2-Methoxypropanoic acid

Chemical Property:

• Vapor Pressure: 0.144mmHg at 25°C
• Melting Point: 128.5 °C
• Boiling Point: 199.4°Cat760mmHg
• PKA: 3.59±0.10(Predicted)
• Flash Point: 87.1°C
• PSA: 46.53000
• Density: 1.085g/cm³
• LogP: 0.10590
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 104.047344113
• Heavy Atom Count: 7
• Complexity: 69.3

Purity/Quality:

98%, ^*data from raw suppliers

2-Methoxypropanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)O)OC

Technology Process of 2-Methoxypropanoic acid

There total 19 articles about 2-Methoxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

sodium methylate (124-41-4) + 2-Bromopropionic acid (598-72-1,10327-08-9) → 2-methoxypropionic acid (4324-37-2)

Guidance literature:

In methanol; at 50 ℃;

Reference yield: 99.0%

methanol (67-56-1) + sodium methylate (124-41-4) + 2-Bromopropionic acid (598-72-1,10327-08-9) → 2-methoxypropionic acid (4324-37-2)

Guidance literature:

methanol; sodium methylate; 2-Bromopropionic acid; at 50 ℃;

With hydrogenchloride; water; pH=1;

Reference yield: 92.0%

ethyl (S)-2-methoxypropanoate (41918-08-5) → 2-methoxypropionic acid (4324-37-2)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1021/ja0042938

upstream raw materials:

methyl 2-methoxypropionate

LACTIC ACID

dimethyl sulfate

sodium methylate

Downstream raw materials:

ethyl 2-methoxypropionate

2-methoxypropanoyl chloride

2-Methoxy-propionic acid 2-phenoxy-ethyl ester

(S)-2-methoxypropanoic acid

Refernces

Decarboxylative diarylation reaction of 2-methoxypropanoic acid in a phosphorus pentoxide-methanesulfonic acid mixture yielding 1,1-diarylethanes

10.1021/jo960103t

2-Methoxypropionic acid (O-methyllactic acid, 1) is a carboxylic acid with a methoxy group attached to the second carbon atom of the propane chain. It is liquid at room temperature and soluble in organic solvents such as methanesulfonic acid and polyphosphoric acid. It is the main reactant in this study. The methoxy and carboxyl groups are essential to the reaction mechanism that ultimately produces 1,1-diarylethane. Phosphorus pentoxide (P2O5) is a compound with the molecular formula P2O5. It is a white crystalline solid that is highly hygroscopic and reacts violently with water to produce phosphoric acid. It acts as a dehydrating agent and a strong acid catalyst in the reaction mixture. It is essential for the oxidative decarboxylation step. The research demonstrates a novel tandem diarylation reaction that selectively forms 1,1-diarylethanes from 2-methoxypropanoic acid in the presence of P2O5-MeSO3H. The reaction shows specific substrate requirements and is influenced by the nucleophilic character of the aromatic compounds used.