4-O-(5'-phenacyloxycarbonylpentanoyl)-15-O-<5'-O-(tetrahydro-2''-pyranyl)mevalonyl>verrucarol

Base Information

• Chemical Name: 4-O-(5'-phenacyloxycarbonylpentanoyl)-15-O-<5'-O-(tetrahydro-2''-pyranyl)mevalonyl>verrucarol
• CAS No.: 78501-53-8
• Molecular Formula: C₄₀H₅₄O₁₂
• Molecular Weight: 726.862
• Mol file: 78501-53-8.mol

Synonyms:

Chemical Property of 4-O-(5'-phenacyloxycarbonylpentanoyl)-15-O-<5'-O-(tetrahydro-2''-pyranyl)mevalonyl>verrucarol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-O-(5'-phenacyloxycarbonylpentanoyl)-15-O-<5'-O-(tetrahydro-2''-pyranyl)mevalonyl>verrucarol

There total 6 articles about 4-O-(5'-phenacyloxycarbonylpentanoyl)-15-O-<5'-O-(tetrahydro-2''-pyranyl)mevalonyl>verrucarol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Adipic acid (124-04-9) → 4-O-(5'-phenacyloxycarbonylpentanoyl)-15-O-<5'-O-(tetrahydro-2''-pyranyl)mevalonyl>verrucarol (78501-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 7.5 g / triethylamine / acetone / Ambient temperature

2: 265 mg / CDI, DBN / benzene / 48 h / Ambient temperature

3: 206 mg / CDI, DBN / benzene / 48 h / 50 °C

With 2,6-dichloro-benzonitrile; triethylamine; 1,1'-carbonyldiimidazole; In acetone; benzene;

DOI:10.1002/hlca.19810640132

Reference yield:

4-(tetrahydropyran-2-yloxy)butan-2-one (20705-59-3) → 4-O-(5'-phenacyloxycarbonylpentanoyl)-15-O-<5'-O-(tetrahydro-2''-pyranyl)mevalonyl>verrucarol (78501-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 25.6 g / zinc / diethyl ether / 4 h / Heating

2: 9.2 percent / 2 N aqu NaOH / methanol / 5 h / Heating

3: 206 mg / CDI, DBN / benzene / 48 h / 50 °C

With sodium hydroxide; 2,6-dichloro-benzonitrile; 1,1'-carbonyldiimidazole; zinc; In methanol; diethyl ether; benzene;

DOI:10.1002/hlca.19810640132

Reference yield:

verrucarol (2198-92-7) → 4-O-(5'-phenacyloxycarbonylpentanoyl)-15-O-<5'-O-(tetrahydro-2''-pyranyl)mevalonyl>verrucarol (78501-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 265 mg / CDI, DBN / benzene / 48 h / Ambient temperature

2: 206 mg / CDI, DBN / benzene / 48 h / 50 °C

With 2,6-dichloro-benzonitrile; 1,1'-carbonyldiimidazole; In benzene;

DOI:10.1002/hlca.19810640132

upstream raw materials:

4-(tetrahydropyran-2-yloxy)butan-2-one

Adipic acid

verrucarol

α-bromoacetophenone