acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester

Base Information

• Chemical Name: acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester
• CAS No.: 438246-25-4
• Molecular Formula: C₃₂H₄₆N₂O₈
• Molecular Weight: 586.726
• Mol file: 438246-25-4.mol

Synonyms:

Chemical Property of acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester

There total 6 articles about acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

tert-butylamine (75-64-9) + acetic acid 2-acetoxymethyl-6-(2-acetoxy-5-oxiranyl-benzyl)-4-oxiranyl-phenyl ester (438246-24-3) → acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester (438246-25-4)

Guidance literature:

With isopropyl alcohol; for 2h; Heating;

DOI:10.1016/S0040-4039(01)02354-1

Reference yield:

4-bromo-phenol (106-41-2) → acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester (438246-25-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 94 percent / H₂SO₄ / 18 h / -10 - 0 °C

2: 38 percent / NaOH / 72 h / 50 °C

3: 94 percent / DMAP; pyridin / 2 h

4: 50 percent / PdCl₂(PPh₃)2 / toluene / 95 °C

5: 98 percent / NBS; aq. DMSO / 0.5 h

6: 57 percent / NaH / dimethylformamide; tetrahydrofuran / 0.5 h

7: 66 percent / isopropanol / 2 h / Heating

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-Bromosuccinimide; sulfuric acid; sodium hydride; dimethyl sulfoxide; isopropyl alcohol; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(01)02354-1

Reference yield:

4-Bromo-2-(5-bromo-2-hydroxy-benzyl)-6-hydroxymethyl-phenol (438246-20-9) → acetic acid 2-[2-acetoxy-5-(2-tert-butylamino-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-tert-butylamino-1-hydroxy-ethyl)-phenyl ester (438246-25-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 94 percent / DMAP; pyridin / 2 h

2: 50 percent / PdCl₂(PPh₃)2 / toluene / 95 °C

3: 98 percent / NBS; aq. DMSO / 0.5 h

4: 57 percent / NaH / dimethylformamide; tetrahydrofuran / 0.5 h

5: 66 percent / isopropanol / 2 h / Heating

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; sodium hydride; dimethyl sulfoxide; isopropyl alcohol; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(01)02354-1

upstream raw materials:

tert-butylamine

acetic acid 2-acetoxymethyl-6-(2-acetoxy-5-oxiranyl-benzyl)-4-oxiranyl-phenyl ester

4-bromo-phenol

4-Bromo-2-(5-bromo-2-hydroxy-benzyl)-6-hydroxymethyl-phenol

Downstream raw materials:

salbutamol dimer