(4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide

Base Information

Chemical Name:(4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide
CAS No.:922516-88-9
Molecular Formula:C₃₅H₅₇NO₆Si₂
Molecular Weight:644.012
Hs Code.:

(4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide

Synonyms:

Suppliers and Price of (4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide

There total 5 articles about (4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4R,5S)-5-[(1R,3R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-3-triethylsilanyloxy-butyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 922516-88-9
(4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.tetasy.2006.10.024

Reference yield:

: 922516-84-5
(4R,6R)-7-(tert-butyldiphenylsilyloxy)-6-hydroxy-4-methylhept-2E-enoic acid ethyl ester

: 922516-88-9
(4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / AD-mix-α; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 18 h / 0 °C

2: 76 percent / camphorsulfonic acid; molecular sieves 3 Angstroem / acetone / 18 h / 20 °C

3: 97 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

4: Me₃SiOK / tetrahydrofuran / 1 h / 20 °C

5: 458 mg / N-methylmorpholine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h / 20 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; AD-mix-α; methanesulfonamide; 3 A molecular sieve; camphor-10-sulfonic acid; potassium trimethylsilonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; 1: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tetasy.2006.10.024

Reference yield:

: 922516-86-7
(4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-hydroxypent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid ethyl ester

: 922516-88-9
(4R,5S)-5-[(2R,4R)-5-(tert-butyldiphenylsilyloxy)-4-(triethylsilyloxy)pent-2-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid N-methoxy-N-methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

2: Me₃SiOK / tetrahydrofuran / 1 h / 20 °C

3: 458 mg / N-methylmorpholine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h / 20 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; potassium trimethylsilonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2006.10.024