Technology Process of 2-(1-C-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)methyl)propene
There total 7 articles about 2-(1-C-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)methyl)propene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
Inert atmosphere;
1-C-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)propan-2-one;
In
tetrahydrofuran;
at 0 ℃;
for 8h;
Inert atmosphere;
DOI:10.1021/jo2024569
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridinium p-toluenesulfonate / benzene / 3 h / Inert atmosphere; Reflux
2.1: methanol; sodium / 2 h / 0 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
3.2: 6 h / 20 °C / Inert atmosphere
4.1: water; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere
5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
5.2: 8 h / 0 °C / Inert atmosphere
With
methanol; potassium tert-butylate; water; sodium; pyridinium p-toluenesulfonate; sodium hydride; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
5.1: Wittig reaction / 5.2: Wittig reaction;
DOI:10.1021/jo2024569
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran / 70 - 100 °C / Microwave irradiation; Inert atmosphere
2.1: pyridine
3.1: pyridinium p-toluenesulfonate / benzene / 3 h / Inert atmosphere; Reflux
4.1: methanol; sodium / 2 h / 0 °C / Inert atmosphere
5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
5.2: 6 h / 20 °C / Inert atmosphere
6.1: water; trifluoroacetic acid / dichloromethane / 0.5 h / Inert atmosphere
7.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
7.2: 8 h / 0 °C / Inert atmosphere
With
pyridine; methanol; potassium tert-butylate; water; sodium; pyridinium p-toluenesulfonate; sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
7.1: Wittig reaction / 7.2: Wittig reaction;
DOI:10.1021/jo2024569
