4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Chemical Name:4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
CAS No.:356535-38-1
Molecular Formula:C₄₀H₄₄N₅O₁₃PS
Molecular Weight:865.855
Hs Code.:

4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of 4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

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Technology Process of 4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 9 articles about 4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 356535-50-7
C₆₁H₆₂N₅O₁₅PS

: 356535-38-1
4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: With dichloro-acetic acid; pyrrole; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1039/b208802a

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 356535-38-1
4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N; DMAP / CH₂Cl₂ / 1 h / 20 °C

2: 1.74 g / dichloroacetic acid; pyrrole / CH₂Cl₂ / 0.25 h / 20 °C

3: pyridine

4: diphenylphosphorochloridate; pyridine / 0.17 h / 20 °C

5: 6.10 g / Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 0.17 h / 0 °C

With pyridine; dichloro-acetic acid; dmap; pyrrole; triethylamine; chlorophosphoric acid diphenyl ester; In dichloromethane;
DOI:10.1039/b208802a

Reference yield:

: 528569-40-6
5'-O-(4,4'-dimethoxytrityl)-4-O-phenylthymidine

: 356535-38-1
4-oxo-pentanoic acid 2-{(2-cyano-ethylsulfanyl)-[2-hydroxymethyl-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(5-methyl-2-oxo-4-phenoxy-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N; DMAP / CH₂Cl₂ / 1 h / 20 °C

2: 1.74 g / dichloroacetic acid; pyrrole / CH₂Cl₂ / 0.25 h / 20 °C

3: pyridine

4: diphenylphosphorochloridate; pyridine / 0.17 h / 20 °C

5: 6.10 g / Cl₂CHCO₂H; pyrrole / CH₂Cl₂ / 0.17 h / 0 °C

With pyridine; dichloro-acetic acid; dmap; pyrrole; triethylamine; chlorophosphoric acid diphenyl ester; In dichloromethane;
DOI:10.1039/b208802a