2H-Indol-2-one, 1,3-dihydro-5-iodo-1,3,3-trimethyl-

Base Information

• Chemical Name: 2H-Indol-2-one, 1,3-dihydro-5-iodo-1,3,3-trimethyl-
• CAS No.: 139487-11-9
• Molecular Formula: C11H12INO
• Molecular Weight: 301.127
• Mol file: 139487-11-9.mol

Synonyms:5-IODO-1,3,3-TRIMETHYL-2,3-DIHYDRO-1H-INDOL-2-ONE;5-iodo-1,3,3-trimethylindolin-2-one;5-IODO-1,3,3-TRIMETHYL-2-OXOINDOLINE;

Chemical Property of 2H-Indol-2-one, 1,3-dihydro-5-iodo-1,3,3-trimethyl-

Chemical Property:

• PSA: 20.31000
• LogP: 2.61020

Purity/Quality:

97% ^*data from raw suppliers

5-Iodo-1,3,3-trimethyl-2-oxoindoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Indol-2-one, 1,3-dihydro-5-iodo-1,3,3-trimethyl-

There total 2 articles about 2H-Indol-2-one, 1,3-dihydro-5-iodo-1,3,3-trimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-iodo-1,3-dihydro-indol-2-one (193354-13-1) + methyl iodide (74-88-4) → 5-iodo-1,3,3-trimethylindolin-2-one (139487-11-9)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2012.07.024

Reference yield:

1,2,3,3-tetramethyl-3H-indolium iodide (5418-63-3) → 1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one (20200-86-6) + 5-iodo-1,3,3-trimethylindolin-2-one (139487-11-9)

Guidance literature:

With methanesulfonic acid; iodine; dimethyl sulfoxide; at 100 ℃; for 2h; Temperature; Overall yield = 35 percent;

DOI:10.1177/1747519819875862

Reference yield: 15.0%

(2-amino-5,10,15,20-tetraphenylporphyrinato)-nickel(II) (189192-29-8) + 5-iodo-1,3,3-trimethylindolin-2-one (139487-11-9) + 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl (76144-87-1,76189-55-4,76189-56-5,136655-44-2,98327-87-8) → (2-phenylamino-5,10,15,20-tetraphenylporphyrinato)nickel(II) (1058186-88-1) + C55H40N6NiO (1398163-02-4)

Guidance literature:

With potassium tert-butylate; palladium diacetate; In toluene; at 100 - 110 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2012.07.024

upstream raw materials:

5-iodo-1,3-dihydro-indol-2-one

methyl iodide

1,2,3,3-tetramethyl-3H-indolium iodide

Downstream raw materials:

(2-phenylamino-5,10,15,20-tetraphenylporphyrinato)nickel(II)

C₅₅H₄₀N₆NiO