1-(3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)-N-methylmethanamine

Base Information

• Chemical Name: 1-(3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)-N-methylmethanamine
• CAS No.: 1311146-72-1
• Molecular Formula: C₁₆H₂₁N₃
• Molecular Weight: 255.363
• Mol file: 1311146-72-1.mol

Synonyms:

Chemical Property of 1-(3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)-N-methylmethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)-N-methylmethanamine

There total 4 articles about 1-(3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazole (1311146-75-4) + methylamine hydrochloride (593-51-1) → 1-(3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)-N-methylmethanamine (1311146-72-1)

Guidance literature:

formaldehyd; methylamine hydrochloride; In ethanol; at 60 ℃; for 2h; Inert atmosphere;

3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazole; In ethanol; at 75 ℃; for 21h; Inert atmosphere;

DOI:10.1021/jm2003365

Reference yield:

3,5-dimethyl-1H-pyrazole (67-51-6) → 1-(3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)-N-methylmethanamine (1311146-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 10 h / 110 °C / Inert atmosphere

2.2: KF/Celite_.(C). / 24 h / 20 °C / Inert atmosphere

3.1: ethanol / 2 h / 60 °C / Inert atmosphere

3.2: 21 h / 75 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hydroxide; In ethanol; dimethyl sulfoxide; toluene; 2.1: Stille coupling / 2.2: Stille coupling / 3.1: Mannich-type reaction / 3.2: Mannich-type reaction;

DOI:10.1021/jm2003365

Reference yield:

2-bromobenzylchloride (578-51-8) → 1-(3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)-N-methylmethanamine (1311146-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 10 h / 110 °C / Inert atmosphere

2.2: KF/Celite_.(C). / 24 h / 20 °C / Inert atmosphere

3.1: ethanol / 2 h / 60 °C / Inert atmosphere

3.2: 21 h / 75 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hydroxide; In ethanol; dimethyl sulfoxide; toluene; 2.1: Stille coupling / 2.2: Stille coupling / 3.1: Mannich-type reaction / 3.2: Mannich-type reaction;

DOI:10.1021/jm2003365

upstream raw materials:

3,5-dimethyl-1H-pyrazole

formaldehyd

3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazole

methylamine hydrochloride

Downstream raw materials:

1-(4-chlorophenoxy)-3-(((3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)methyl)(methyl)amino)propan-2-ol

1-(((3,5-dimethyl-1-(2-vinylbenzyl)-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-ethoxyphenoxy)propan-2-ol