Benzo[d]oxazole-2-carboxylic acid, potassium salt

Base Information

• Chemical Name: Benzo[d]oxazole-2-carboxylic acid, potassium salt
• CAS No.: 119130-94-8
• Molecular Formula: C₈H₄NO₃*K
• Molecular Weight: 201.223
• Mol file: 119130-94-8.mol

Synonyms:

Chemical Property of Benzo[d]oxazole-2-carboxylic acid, potassium salt

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Benzo[d]oxazole-2-carboxylicacid,potassiumsalt 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Potassium Benzo[d]oxazole-2-carboxylate is used in the synthesis of novel negative allosteric modulators of the dopamine D2 receptor.

Technology Process of Benzo[d]oxazole-2-carboxylic acid, potassium salt

There total 4 articles about Benzo[d]oxazole-2-carboxylic acid, potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[Cu(1,3-bis(diisopropyl)phenylimidazol-2-ylidene)(C7H4NOCO2)] → potassium benzo[d]oxazole-2-carboxylate (119130-94-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201003995

Reference yield: 98.0%

benzoxazole-2-carboxylic acid methyl ester (27383-86-4) → potassium benzo[d]oxazole-2-carboxylate (119130-94-8)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

DOI:10.1016/j.dyepig.2019.107604

Reference yield:

benzoxazole (273-53-0,29791-96-6) + carbon dioxide (124-38-9,18923-20-1) → potassium benzo[d]oxazole-2-carboxylate (119130-94-8)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 100 ℃; for 18h; under 760.051 Torr; Reagent/catalyst; Solvent; Temperature; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1039/c6gc00200e

upstream raw materials:

benzoxazole

carbon dioxide

2-amino-phenol

benzoxazole-2-carboxylic acid methyl ester

Downstream raw materials:

benzoxazole-2-carboxylic acid methyl ester