1-benzyl-5-(4-chlorobenzylidene)-4'-(4-chlorophenyl)-1'-methyl-2,3-dihydro-1H-indole-3-spiro-2'-pyrrolidine-3'-spiro-3-piperidine-2,3-dione

Base Information

• Chemical Name: 1-benzyl-5-(4-chlorobenzylidene)-4'-(4-chlorophenyl)-1'-methyl-2,3-dihydro-1H-indole-3-spiro-2'-pyrrolidine-3'-spiro-3-piperidine-2,3-dione
• CAS No.: 1231767-70-6
• Molecular Formula: C₃₆H₃₁Cl₂N₃O₂
• Molecular Weight: 608.567

Synonyms:

Chemical Property of 1-benzyl-5-(4-chlorobenzylidene)-4'-(4-chlorophenyl)-1'-methyl-2,3-dihydro-1H-indole-3-spiro-2'-pyrrolidine-3'-spiro-3-piperidine-2,3-dione

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Technology Process of 1-benzyl-5-(4-chlorobenzylidene)-4'-(4-chlorophenyl)-1'-methyl-2,3-dihydro-1H-indole-3-spiro-2'-pyrrolidine-3'-spiro-3-piperidine-2,3-dione

There total 1 articles about 1-benzyl-5-(4-chlorobenzylidene)-4'-(4-chlorophenyl)-1'-methyl-2,3-dihydro-1H-indole-3-spiro-2'-pyrrolidine-3'-spiro-3-piperidine-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

sarcosine (107-97-1,25951-24-0) + 3,5-bis-(4-chlorophenylmethylene)-1-benzylpiperidin-4-one (331839-41-9) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 1-benzyl-5-(4-chlorobenzylidene)-4'-(4-chlorophenyl)-1'-methyl-2,3-dihydro-1H-indole-3-spiro-2'-pyrrolidine-3'-spiro-3-piperidine-2,3-dione (1231767-70-6)

Guidance literature:

In methanol; for 24h; regioselective reaction; Reflux;

DOI:10.1002/cjoc.201090092

Reference yield: 80.0%

1-benzyl-5-(4-chlorobenzylidene)-4'-(4-chlorophenyl)-1'-methyl-2,3-dihydro-1H-indole-3-spiro-2'-pyrrolidine-3'-spiro-3-piperidine-2,3-dione (1231767-70-6) + 2,6-dichlorobenzonitrile N-oxide (2904-62-3) → 1'-benzyl-4,4''-bis-(4-chlorophenyl)-3-(2,6-dichlorophenyl)-1-methyl-4,5,2''',3'''-tetrahydro-1'''H-isoxazole-5-spiro-3'-piperidine-5'-spiro-3-pyrrolidine-2-spiro-3'''-1-indole-2''',4'-dione (1231767-76-2)

Guidance literature:

In benzene; for 24h; regioselective reaction; Reflux;

DOI:10.1002/cjoc.201090092

upstream raw materials:

sarcosine

3,5-bis-(4-chlorophenylmethylene)-1-benzylpiperidin-4-one

indole-2,3-dione

Downstream raw materials:

1'-benzyl-4,4''-bis-(4-chlorophenyl)-3-(2,6-dichlorophenyl)-1-methyl-4,5,2''',3'''-tetrahydro-1'''H-isoxazole-5-spiro-3'-piperidine-5'-spiro-3-pyrrolidine-2-spiro-3'''-1-indole-2''',4'-dione

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